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William Wallace
Researcher at Royal Hospital for Sick Children
Publications - 166
Citations - 11429
William Wallace is an academic researcher from Royal Hospital for Sick Children. The author has contributed to research in topics: Fertility preservation & Cancer. The author has an hindex of 50, co-authored 159 publications receiving 10261 citations. Previous affiliations of William Wallace include Air Force Research Laboratory & University of Edinburgh.
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Data-driven assessment of the human ovarian reserve.
TL;DR: This paper can hypothesize that age is the most important factor for variations in individual ovarian non-growing follicle (NGF) populations, that anti-Müllerian hormone (AMH) levels generally rise and fall in childhood years before peaking in the mid-twenties, and that there are strong correlations between AMH levels and both NGF populations and rates of recruitment towards maturation.
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Long term follow-up of survivors of childhood cancer: summary of updated SIGN guidance
TL;DR: This article summarises the most recently updated recommendations from SIGN, based on systematic reviews of best available evidence, on subsequent primary cancers, fertility, cardiac and bone health, and metabolic effects.
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Fertility preservation for children treated for cancer (1): scientific advances and research dilemmas
Richard Grundy,R G Gosden,Martin Hewitt,V Larcher,A Leiper,Helen Spoudeas,David Walker,William Wallace +7 more
TL;DR: Rapid developments in assisted reproduction techniques (ART) now raise the possibility of cryopreserving gonadal tissue to conserve the fertility of young cancer patients, which raises major practical, scientific, and ethical issues.
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Testicular changes during infantile ‘quiescence’ in the marmoset and their gonadotrophin dependence: a model for investigating susceptibility of the prepubertal human testis to cancer therapy?
Christopher J. H. Kelnar,Chris McKinnell,Marion F Walker,K D Morris,William Wallace,Philippa T. K. Saunders,Hamish M. Fraser,R. M. Sharpe +7 more
TL;DR: The findings reinforce the view that the 'childhood' testis is not quiescent, and suggest that GnRH antagonist-based intervention might be only partially successful in establishing testicular cell function/activity between the neonatal period and puberty.
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Preservation of fertility in children treated for cancer
William Wallace,A.B. Thomson +1 more
TL;DR: Limitation of radiation exposure by shielding of the testes and ovaries should be practiced where possible and sperm banking should be offered to all sexually mature boys at risk of infertility.