W
Wilma Sumoski
Researcher at University of Alberta
Publications - 5
Citations - 462
Wilma Sumoski is an academic researcher from University of Alberta. The author has contributed to research in topics: Islet & Tumor necrosis factor alpha. The author has an hindex of 5, co-authored 5 publications receiving 455 citations.
Papers
More filters
Journal ArticleDOI
Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture.
TL;DR: The findings indicate that IL-1 and TNF, as single agents, are cytotoxic to human islet cells, and that this cytotoxicity can be amplified by combining the cytokines and/or adding IFN gamma.
Journal ArticleDOI
Oxygen free radical scavengers protect rat islet cells from damage by cytokines.
TL;DR: The cytokine products of macrophages and lymphocytes infiltrating islets in Type 1 (insulin-dependent) diabetes may contribute to B-cell damage by inducing the production of oxygen free radicals in the islet cells.
Journal ArticleDOI
Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant
Michel Sadelain,Hui-Yu Qin,Wilma Sumoski,Nollaig A. Parfrey,Bhagirath Singh,Alex Rabinovitch +5 more
TL;DR: A single intraperitoneal injection of complete Freund's adjuvant in diabetes-prone BB/Wor rats between 9 and 28 years of age reduced the incidence of diabetes at 120 days from 89% to 10-28%, whereas injection of CFA after 40 days of age was ineffective.
Journal ArticleDOI
Cytotoxic Effects of Cytokines on Islet β-Cells: Evidence for Involvement of Eicosanoids*
TL;DR: Results suggest that arachidonate metabolites may be involved in mediating the cytotoxic and not the functional inhibitory effects of TNF and IFN-gamma in islet cells.
Journal ArticleDOI
Theophylline protects against diabetes in BB rats and potentiates cyclosporine protection.
Alex Rabinovitch,Wilma Sumoski +1 more
TL;DR: Protection against diabetes by theophylline and cyclosporine was associated with preservation of pancreatic Beta cell mass (insulin content) and it is suggested that theophylla may be a useful adjunct in the immunosuppressive therapy of Type 1 diabetes.