Winfried Stoecker

TL;DR: Acutely ill patients with an initial schizophrenia diagnosis show an increased prevalence of NMDA-R antibodies and the repertoire of antibody subtypes in schizophrenia and MD is different from that with NMda-R encephalitis.

TL;DR: Six of 7 cases with the indicated clinical criteria had anti-NMDAR encephalitis, which represented 1% of all young patients' admissions to the ICU, and NMDAR antibodies should be tested in all patients withEncephalitis who fulfill these criteria.

TL;DR: Indirect immunofluorescence using NMDA-type glutamate receptors recombinantly expressed in human cells is a highly competent method for diagnosing anti-NMDA-receptor encephalitis.

TL;DR: The recombinant IFA presented here provides laboratories familiar with indirect immunofluorescence microscopy with a highly sensitive and reproducible diagnostic tool for standardized detection of antibodies to AQP4.

TL;DR: A subset of patients with slowly progressive cognitive impairment has an underlying synaptic autoimmunity that decreases the density of NMDAR and other synaptic proteins, and alters synaptic currents, and can be demonstrated examining patients' serum and CSF for N MDAR IgA antibodies, identifying possible candidates for immunotherapy.