W
Winifred Keeble
Researcher at Oregon Health & Science University
Publications - 24
Citations - 1449
Winifred Keeble is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Fanconi anemia & Fanconi anemia, complementation group C. The author has an hindex of 16, co-authored 24 publications receiving 1424 citations. Previous affiliations of Winifred Keeble include Portland VA Medical Center.
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Journal ArticleDOI
A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin.
Paul W. Cook,Paul A. Mattox,Winifred Keeble,M. R. Pittelkow,Greg Plowman,Mohammed Shoyab,J. P. Adelman,Gary D. Shipley +7 more
TL;DR: In this article, a novel human keratinocyte-derived autocrine factor (KAF) was purified from conditioned medium by using heparin affinity chromatography as the first step.
Journal Article
Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas.
Paul W. Cook,Mark R. Pittelkow,Winifred Keeble,Ramona Graves-Deal,Robert J. Coffey,Gary D. Shipley +5 more
TL;DR: It is demonstrated that, compared with the adjacent uninvolved epithelium, AR mRNA expression is markedly elevated in epidermal biopsies derived from three human psoriatic lesions as well as in biopsie derived from five human colon carcinomas and three human stomach carcinomas.
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Growth of normal human keratinocytes and fibroblasts in serum-free medium is stimulated by acidic and basic fibroblast growth factor.
TL;DR: The results demonstrate that the proliferation in vitro of two normal cell types found in the skin can be influenced by aF GF and bFGF and demonstrate cell‐type specific differences in the responsiveness of fibroblasts and keratinocytes to these growth factors and heparin.
Journal ArticleDOI
Constitutive expression of steel factor gene by human stromal cells
Michael Heinrich,Douglas C. Dooley,AC Freed,Maureen E. Hoatlin,Winifred Keeble,Peters St,Kirsten V. Silvey,Frederick S. Ey,David Kabat +8 more
TL;DR: It is concluded that the unique capacity of LTBMC to support in vitro hematopoiesis, when compared with EC or DF, cannot be explained on the basis of qualitative or quantitative differences in SF gene expression in these cells.
Journal ArticleDOI
The Anti-apoptotic Function of Hsp70 in the Interferon-inducible Double-stranded RNA-dependent Protein Kinase-mediated Death Signaling Pathway Requires the Fanconi Anemia Protein, FANCC
Qishen Pang,Qishen Pang,Tracy A. Christianson,Winifred Keeble,Tara Koretsky,Grover C. Bagby,Grover C. Bagby +6 more
TL;DR: It is concluded that Hsp70 requires the cooperation of FANCC to suppress PKR activity and support survival of hematopoietic cells and that FAN CC does not require the multimeric FA complex to exert this function.