W
Wojciech Jóźwicki
Researcher at Nicolaus Copernicus University in Toruń
Publications - 44
Citations - 1210
Wojciech Jóźwicki is an academic researcher from Nicolaus Copernicus University in Toruń. The author has contributed to research in topics: Melanoma & Calcitriol receptor. The author has an hindex of 18, co-authored 44 publications receiving 993 citations. Previous affiliations of Wojciech Jóźwicki include Memorial Hospital of South Bend.
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Journal ArticleDOI
The role of melanogenesis in regulation of melanoma behavior: Melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways
Andrzej Slominski,Tae Kang Kim,Anna A. Brożyna,Zorica Janjetovic,D. L.P. Brooks,Luciana P. Schwab,Cezary Skobowiat,Wojciech Jóźwicki,Tiffany N. Seagroves +8 more
TL;DR: Induction of the melanogenic pathway leads to robust upregulation of HIF-1-dependent and independent pathways in cultured melanoma cells, suggesting a key role for melanogenesis in regulation of cellular metabolism.
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Melanin content in melanoma metastases affects the outcome of radiotherapy.
Anna A. Brożyna,Wojciech Jóźwicki,Wojciech Jóźwicki,Krzysztof Roszkowski,Jan Filipiak,Andrzej Slominski +5 more
TL;DR: It is suggested that inhibition of melanogenesis can improve radiotherapy modalities and the mechanism of relationship between melanogenesis and efficacy of RTH requires additional studies, including larger melanoma patients population and orthotopic, imageable mouse models of metastatic melanoma.
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Melanogenesis affects overall and disease-free survival in patients with stage III and IV melanoma
TL;DR: In patients with metastatic disease, those with melanotic melanomas exhibited significantly shorter disease-free survival and overall survival than those with amelanotic lesions, and inhibition of melanogenesis appears a rational adjuvant approach to the therapy of metastatic melanoma.
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Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management
Andrzej Slominski,Anna A. Brożyna,Anna A. Brożyna,Michal A. Zmijewski,Wojciech Jóźwicki,Wojciech Jóźwicki,Anton M. Jetten,Rebecca S. Mason,Robert C. Tuckey,Craig A. Elmets +9 more
TL;DR: It is proposed that defects in vitamin D signaling including D3 activation/inactivation, and the expression and activity of the corresponding receptors, affect melanoma progression and the outcome of the disease.
Journal Article
Decreased VDR expression in cutaneous melanomas as marker of tumor progression: new data and analyses.
TL;DR: High VDR expression determines a less malignant phenotype and is related to better prognosis, and can also serve as a prognostic marker in routine histopathology evaluation.