Michal A. Zmijewski

TL;DR: In conclusion, skin cells and skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.

TL;DR: There is evidence that L-tyrosine and L-dihydroxyphenylalanine (L-DOPA) are also bioregulatory agents acting not only as inducers and positive regulators of melanogenesis but also as regulators of other cellular functions as discussed by the authors.

TL;DR: This work focused on the CRF-led signaling systems in the skin and offered a model for regulation of peripheral homeostasis based on the interaction of CRF and the structurally related urocortins with corresponding receptors and the resulting direct or indirect phenotypic effects that include regulation of epidermal barrier function, skin immune, pigmentary, adnexal, and dermal functions necessary to maintain local and systemic homeostasi.

TL;DR: The skin can be defined as an independent steroidogenic organ, whose activity can affect its functions and the development of local or systemic inflammatory or autoimmune diseases.

TL;DR: The properties of endogenous melatonin suggest that this molecule is an important effector of stress responses in the skin, and actions may counteract or buffer both environmental and endogenous stressors to maintain skin integrity.