R
Robert C. Tuckey
Researcher at University of Western Australia
Publications - 150
Citations - 7873
Robert C. Tuckey is an academic researcher from University of Western Australia. The author has contributed to research in topics: Calcitriol receptor & Cholesterol side-chain cleavage enzyme. The author has an hindex of 49, co-authored 143 publications receiving 6533 citations. Previous affiliations of Robert C. Tuckey include University of Tennessee Health Science Center.
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Journal ArticleDOI
Steroidogenesis in the skin: Implications for local immune functions
Andrzej Slominski,Blazej Zbytek,Georgios Nikolakis,Pulak R. Manna,Cezary Skobowiat,Michal A. Zmijewski,Wei Li,Zorica Janjetovic,Arnold E. Postlethwaite,Christos C. Zouboulis,Robert C. Tuckey +10 more
TL;DR: The skin can be defined as an independent steroidogenic organ, whose activity can affect its functions and the development of local or systemic inflammatory or autoimmune diseases.
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Differential expression of HPA axis homolog in the skin.
TL;DR: Differential, CRH-driven responses of defined cutaneous cell populations reproduce key features of the central HPA axis at the tissue/single cell levels.
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Progesterone synthesis by the human placenta
TL;DR: Cyclone AMP stimulates progesterone synthesis by the human placenta but uncertainty remains regarding the key hormones that control cyclic AMP levels.
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A novel pathway for sequential transformation of 7‐dehydrocholesterol and expression of the P450scc system in mammalian skin
Andrzej Slominski,Jordan K. Zjawiony,Jacobo Wortsman,Igor Semak,Jeremy Stewart,Alexander Pisarchik,Trevor W. Sweatman,Josep Marcos,Chuck Dunbar,Robert C. Tuckey +9 more
TL;DR: 7-DHC can form 7-DHP through P450scc side-chain cleavage, which may serve as a substrate for further conversions into hydroxy derivatives through existing steroidogenic enzymes, and has the potential to generate a variety of molecules depending on local steroidogenic activity and access to UVB.
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In vivo evidence for a novel pathway of vitamin D3 metabolism initiated by P450scc and modified by CYP27B1
Andrzej Slominski,Tae Kang Kim,Haleem Z. Shehabi,Igor Semak,Edith K.Y. Tang,Minh N. Nguyen,Heather A. E. Benson,Elena Korik,Zorica Janjetovic,Jianjun Chen,Charles R. Yates,Arnold E. Postlethwaite,Wei Li,Robert C. Tuckey +13 more
TL;DR: The pathway intermediates are defined as natural products/endogenous bioregulators and break the current dogma that vitamin D is solely activated through the sequence D3 → 25(OH)D3 → 1,25( OH)2D3.—Slominski, A. C.