Wojciech Streciwilk

TL;DR: In this paper, the synthesis, characterization, and biological evaluation of novel Ru(II)- and Au(I)-N-heterocyclic carbenes is reported, and the ligand exchange on the NHC-gold(I) chlorides was achieved by either reacting the complexes with silver acetate to yield the N HC-gold-I) acetates (NHC-Au(I)/OAc) 10−12 or reacting the NOC-gold (I)/Cl chloride complexes (NOC-A/Cl) under basic conditions with 2′

TL;DR: The imidazolium halide precursors 3a–j showed bacterial growth inhibition in the range of 1–5 mm (weak) while their NHC–silver(I) acetate derivatives 4a–g and 4i–j were found to inhibit bacterial growth in range 2–6 mm (weak to medium).

TL;DR: In this article, the N-heterocyclic carbene (NHC) precursors were synthesized by reacting 4,5-bisaryl-1H-imidazole with 2 equivalents of 4-benzyl bromide, 4-methyl-bromide or 4-cyanobenzyl Bromide.

TL;DR: This is the first demonstration of the in vivo activity of SBC3 against S. aureus and C. albicans and demonstrates that S BC3 does not stimulate a non-specific immune response in larvae.

TL;DR: These values represent improved cytotoxicity against both cell lines, especially for the silver complexes 2a and 2b, which are not only more active than SBC3 but also exhibit in the case of 2b a 7 times higher biological activity than cisplatin.