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Wolfgang Hübner
Researcher at Bielefeld University
Publications - 58
Citations - 3273
Wolfgang Hübner is an academic researcher from Bielefeld University. The author has contributed to research in topics: Virus & Microscopy. The author has an hindex of 20, co-authored 49 publications receiving 2708 citations. Previous affiliations of Wolfgang Hübner include Icahn School of Medicine at Mount Sinai & European Bioinformatics Institute.
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Journal ArticleDOI
Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses
Wolfgang Hübner,Gregory P. McNerney,Ping Chen,Benjamin M. Dale,Ronald E. Gordon,Frank Y. S. Chuang,Xiao Dong Li,David M. Asmuth,Thomas R Huser,Benjamin K. Chen +9 more
TL;DR: HIV dissemination may be enhanced by virological synapse-mediated cell adhesion coupled to viral endocytosis, as shown by rapid formation of micrometer-sized “buttons” containing oligomerized viral Gag protein.
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Predominant Mode of Human Immunodeficiency Virus Transfer between T Cells Is Mediated by Sustained Env-Dependent Neutralization-Resistant Virological Synapses
TL;DR: The polarized T-cell morphology, Env-CD4 coordinated adhesion, and viral transfer from HIV-infected to uninfected cells suggest that VS allows HIV-1 to evade antibody neutralization and to disseminate efficiently.
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Open-source image reconstruction of super-resolution structured illumination microscopy data in ImageJ
TL;DR: This work presents fairSIM, an easy-to-use plugin that provides SR-SIM reconstructions for a wide range ofSR-SIM platforms directly within ImageJ, and can easily be adapted, automated and extended as the field of SR- SIM progresses.
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Sequence of Human Immunodeficiency Virus Type 1 (HIV-1) Gag Localization and Oligomerization Monitored with Live Confocal Imaging of a Replication-Competent, Fluorescently Tagged HIV-1
TL;DR: A replication-competent HIV type 1 molecular clone that carries a Gag-internal or interdomain green fluorescent protein (iGFP) fusion to reveal a physiologically accurate temporal sequence of Gag localization and oligomerization during the formation of infectious HIV.
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Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors
Henk de Vries,Ursula Rüegsegger,Ursula Rüegsegger,Wolfgang Hübner,Arno Friedlein,Hanno Langen,Walter Keller +6 more
TL;DR: This article reported the cloning of hClp1 and showed that it is a genuine subunit of CF IIA(m) from HeLa cell nuclear extract by several chromatographic steps.