W
Wolfhard Semmler
Researcher at Free University of Berlin
Publications - 191
Citations - 6720
Wolfhard Semmler is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Magnetic resonance imaging & Imaging phantom. The author has an hindex of 44, co-authored 191 publications receiving 6493 citations. Previous affiliations of Wolfhard Semmler include Humboldt University of Berlin & Katholieke Universiteit Leuven.
Papers
More filters
Journal ArticleDOI
Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands.
Andreas Becker,Carsten Hessenius,Kai Licha,Bernd Ebert,Uwe Sukowski,Wolfhard Semmler,Bertram Wiedenmann,Carsten Grötzinger +7 more
TL;DR: In vivo diagnostic use of a peptide–dye conjugate consisting of a cyanine dye and the somatostatin analog octreotate as a contrast agent for optical tumor imaging, combining the specificity of ligand/receptor interaction with near-infrared fluorescence detection is reported.
Journal ArticleDOI
Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner
Chunfu Zhang,Manfred Jugold,Eva C. Woenne,Twan Lammers,Bernd Morgenstern,Margareta M. Mueller,Hanswalter Zentgraf,Michael Bock,Michael Eisenhut,Wolfhard Semmler,Fabian Kiessling +10 more
TL;DR: RGD-coupled, APTMS-coated USPIOs efficiently label alpha(v)beta(3) integrins expressed on endothelial cells and are capable of distinguishing tumors differing in the degree of alpha( v) beta( 3) integrin expression and in their angiogenesis profile even when using a clinical 1.5-T MR scanner.
Journal ArticleDOI
Hydrophilic cyanine dyes as contrast agents for near-infrared tumor imaging: synthesis, photophysical properties and spectroscopic in vivo characterization.
TL;DR: Compounds such as 5a are promising contrast agents for optical imaging, and could facilitate highly sensitive and specific detection of breast cancer or other malignancies by utilizing mechanisms similar to contrast-enhanced magnetic resonance imaging or computerized tomography.
Journal ArticleDOI
Sodium MRI using a density-adapted 3D radial acquisition technique
Armin M. Nagel,Frederik Bernd Laun,Marc-André Weber,Christian Matthies,Wolfhard Semmler,Lothar R. Schad +5 more
TL;DR: It is shown that the density‐adapted three‐dimensional radial projection reconstruction pulse sequence allows higher resolutions and is more robust in the presence of field inhomogeneities, and benefits for low SNR applications, when compared to conventional three‐ dimensional projection reconstruction sequences.
Journal ArticleDOI
Superparamagnetic iron oxide-enhanced MRI of atherosclerotic plaques in Watanabe hereditable hyperlipidemic rabbits.
Stephan A. Schmitz,Sarah E. Coupland,Robert Gust,Sibylle Winterhalter,Susanne Wagner,Mayk Kresse,Wolfhard Semmler,Karl Jürgen Wolf +7 more
TL;DR: As SPIO accumulates in plaques with increased endothelial permeability and a high macrophage content, two established features of plaque inflammation, it may have a potential for noninvasive assessment of inflammatory atherosclerotic plaques.