W
Won Ki Kim
Researcher at Korea University
Publications - 197
Citations - 7368
Won Ki Kim is an academic researcher from Korea University. The author has contributed to research in topics: Gene & Phylogenetic tree. The author has an hindex of 43, co-authored 169 publications receiving 6766 citations. Previous affiliations of Won Ki Kim include Dongguk University & Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor
Stuart A. Lipton,Won Ki Kim,Yun Beom Choi,Shanta Kumar,Danielle M. D'Emilia,P.V. Rayudu,Derrick R. Arnelle,Jonathan S. Stamler +7 more
TL;DR: It is shown that homocysteine acts as an agonist at the glutamate binding site of the N-methyl-D-aspartate receptor, but also as a partial antagonist of the glycine coagonist site, under pathological conditions in which glycine levels in the nervous system are elevated.
Journal ArticleDOI
Role of oxidative stress in epileptic seizures
Eun-Joo Shin,Ji Hoon Jeong,Yoon Hee Chung,Won Ki Kim,Kwang Ho Ko,Jae Hyung Bach,Jau-Shyong Hong,Yukio Yoneda,Hyoung-Chun Kim +8 more
TL;DR: This review highlights pharmacological mechanisms associated with oxidative stress in epileptic seizures and the potential for neuroprotection in epilepsy that targets oxidative stress and is supported by effective antioxidant treatment.
Journal ArticleDOI
A Taxonomy of Dirty Data
TL;DR: A comprehensive classification of dirty data is developed for use as a framework for understanding how dirty data arise, manifest themselves, and may be cleansed to ensure proper construction of data warehouses and accurate data analysis.
Journal ArticleDOI
α-Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1
Eun Jung Lee,Moon Sook Woo,Pyong Gon Moon,Moon-Chang Baek,In Young Choi,Won Ki Kim,Eunsung Junn,Hee Sun Kim +7 more
TL;DR: MMPs secreted by α-synuclein–stimulated microglia activate PAR-1 and amplify microglial inflammatory signals in an autocrine or paracrine manner and suggest that modulation of the activities of MMPs and/orPAR-1 may provide a new therapeutic strategy for Parkinson’s disease.
Journal ArticleDOI
Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion, NO−
Won Ki Kim,Yun Beom Choi,P.V. Rayudu,Prajnan Das,Wael F. Asaad,Derrick R. Arnelle,Jonathan S. Stamler,Stuart A. Lipton +7 more
TL;DR: It is shown that NO- -unlike NO*, but reminiscent of NO+ transfer (or S-nitrosylation)- -reacts mainly with Cys-399 in the NR2A subunit of the N-methyl-D-aspartate (NMDA) receptor to curtail excessive Ca2+ influx and thus provide neuroprotection from excitotoxic insults.