W
Wouter A. van der Heijden
Researcher at Radboud University Nijmegen
Publications - 20
Citations - 230
Wouter A. van der Heijden is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 12 publications receiving 126 citations.
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Journal ArticleDOI
Platelet microparticles inhibit IL-17 production by regulatory T cells through P-selectin.
Sip Dinkla,Bram van Cranenbroek,Wouter A. van der Heijden,Xuehui He,Rike Wallbrecher,Ingrid E. Dumitriu,André J. A. M. van der Ven,Giel J. C. G. M. Bosman,Hans J. P. M. Koenen,Irma Joosten +9 more
TL;DR: The findings that ~8% of Tregs in the circulation of healthy individuals are CD41(+)P-selectin(+) and that distinct binding of patient plasma PMPs to T Regs was observed support in vivo relevance, opening the exciting possibility that PMPs actively regulate the immune response at sites of (vascular) inflammation.
Journal ArticleDOI
Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells
Wouter A. van der Heijden,Lisa Van de Wijer,Farid Keramati,Wim Trypsteen,Sofie Rutsaert,Rob ter Horst,Martin Jaeger,Hans J. P. M. Koenen,Hendrik G. Stunnenberg,Irma Joosten,Paul E. Verweij,Jan van Lunzen,Charles A. Dinarello,Charles A. Dinarello,Leo A. B. Joosten,Linos Vandekerckhove,Mihai G. Netea,Mihai G. Netea,André J. A. M. van der Ven,Quirijn de Mast +19 more
TL;DR: In this paper, the functional phenotype of immune cells in people living with HIV (PLHIV) was characterized by assessing ex vivo cytokine production capacity and transcriptomics of monocytes and T cells upon bacterial, fungal, and viral stimulation.
Journal ArticleDOI
The XN-30 hematology analyzer for rapid sensitive detection of malaria: a diagnostic accuracy study
Annelies Post,Berenger Kaboré,Isaie J. Reuling,Joel Dofinissery Bognini,Wouter A. van der Heijden,Salou Diallo,Palpouguini Lompo,Basile Kam,Natacha Herssens,Kjerstin Lanke,Teun Bousema,Robert W. Sauerwein,Halidou Tinto,Jan Jacobs,Jan Jacobs,Quirijn de Mast,André J. A. M. van der Ven +16 more
TL;DR: The XN-30 is a novel, automated hematology analyzer that combines standard hemocytometry with rapid, objective, and robust malaria detection and quantification, ensuring prompt treatment of malaria and malaria anemia and follow-up of treatment response.
Journal ArticleDOI
Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.
Guus P. Leijte,Dorien Kiers,Wouter A. van der Heijden,Aron Jansen,Jelle Gerretsen,Verin Boerrigter,Mihai G. Netea,Mihai G. Netea,Matthijs Kox,Peter Pickkers +9 more
TL;DR: Treatment, but not prophylaxis, with low-dose acetylsalicylic acid, partially reverses endotoxin tolerance in humans in vivo by shifting response toward a proinflammatory phenotype.
Journal ArticleDOI
The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation
Lisa Van de Wijer,Wouter A. van der Heijden,Rob ter Horst,Martin Jaeger,Wim Trypsteen,Sofie Rutsaert,Bram van Cranenbroek,Esther van Rijssen,Irma Joosten,Leo A. B. Joosten,Linos Vandekerckhove,Till Schoofs,Jan van Lunzen,Mihai G. Netea,Mihai G. Netea,Hans J. P. M. Koenen,André J. A. M. van der Ven,Quirijn de Mast +17 more
TL;DR: In this article, the authors assessed 108 white blood cell (WBC) populations in a cohort of 211 living with HIV and 56 HIV-uninfected controls using flow cytometry.