W
Wim Trypsteen
Researcher at Ghent University
Publications - 54
Citations - 1276
Wim Trypsteen is an academic researcher from Ghent University. The author has contributed to research in topics: Gene & Digital polymerase chain reaction. The author has an hindex of 15, co-authored 49 publications receiving 870 citations. Previous affiliations of Wim Trypsteen include Ghent University Hospital.
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Journal ArticleDOI
Correction: Corrigendum: Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay
Wim Trypsteen,Pejman Mohammadi,Clarissa Van Hecke,Pieter Mestdagh,Steve Lefever,Yvan Saeys,Pieter De Bleser,Jo Vandesompele,Angela Ciuffi,Linos Vandekerckhove,Ward De Spiegelaere +10 more
TL;DR: In this Article, Yvan Saeys is incorrectly listed as being affiliated with ‘Department of Biomedical Molecular Biology Ghent University, Ghent, Belgium’.
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On the whereabouts of SARS-CoV-2 in the human body: A systematic review.
TL;DR: New light is shed on the current view of SARS-CoV-2 pathogenesis and the foundation for better diagnosis and treatment of COVID-19 patients is laid to construct a viral distribution and ACE2 receptor body map.
Journal ArticleDOI
ddpcRquant: threshold determination for single channel droplet digital PCR experiments
Wim Trypsteen,Matthijs Vynck,Jan De Neve,Pawel Bonczkowski,Maja Kiselinova,Eva Malatinkova,Karen Vervisch,Olivier Thas,Olivier Thas,Linos Vandekerckhove,Ward De Spiegelaere +10 more
TL;DR: This work shows that the normality assumption that the fluorescent signal of droplets is normally distributed does not likely hold true for most ddPCR runs, resulting in an erroneous threshold, and suggests a methodology that does not make any assumptions about the distribution of the fluorescence readouts.
Journal ArticleDOI
Short-Course Toll-Like Receptor 9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals With Human Immunodeficiency Virus Infection
Line K. Vibholm,Line K. Vibholm,Mariane H. Schleimann,Mariane H. Schleimann,Jesper F Højen,Jesper F Højen,Thomas Benfield,Rasmus Offersen,Rasmus Offersen,Katrine Rasmussen,Rikke Olesen,Anders Dige,Anders Dige,Jørgen Agnholt,Jørgen Agnholt,Judith Grau,Maria J. Buzon,Burghardt Wittig,Mathias Lichterfeld,Andreas Petersen,Xutao Deng,Xutao Deng,Mohamed Abdel-Mohsen,Mohamed Abdel-Mohsen,Mohamed Abdel-Mohsen,Satish K. Pillai,Satish K. Pillai,Sofie Rutsaert,Wim Trypsteen,Ward De Spiegelaere,Linos Vandekerchove,Lars Østergaard,Lars Østergaard,Thomas A Rasmussen,Paul W. Denton,Paul W. Denton,Martin Tolstrup,Martin Tolstrup,Ole Schmeltz Søgaard,Ole Schmeltz Søgaard +39 more
TL;DR: TLR9 agonist treatment in HIV infection has a dual potential by increasing HIV-1 transcription and enhancing cytotoxic NK cell activation, both of which are key outcomes in HIV- 1 eradication therapy.
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Digital PCR as a tool to measure HIV persistence.
TL;DR: Quantification of HIV by digital PCR is proving to be a valuable improvement over qPCR as it is argued to have a higher robustness to mismatches between the primers-probe set and heterogeneous HIV, and forfeits the need for a standard curve, both of which are known to complicate reliable quantification.