Matthijs Kox

TL;DR: The transcriptional and metabolic profiling of human patients with sepsis found that a shift from oxidative phosphorylation to aerobic glycolysis was an important component of initial activation of host defense, and the immunometabolic defects in humans were partially restored by therapy with recombinant interferon-γ, which suggested that metabolic processes might represent a therapeutic target in sepsi.

TL;DR: An integrated epigenomic approach is applied to characterize the molecular events involved in LPS-induced tolerance in a time-dependent manner and reveals that tolerance is reversed at the level of distal element histone modification and transcriptional reactivation of otherwise unresponsive genes.

TL;DR: The authors reviewed the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels.

TL;DR: This study compares levels of tumor necrosis factor α, IL-6, and IL-8 in critically ill patients with coronavirus disease 2019 (COVID-19) vs those with other critical illness to better characterize the contribution of cytokine storm to COVID- 19 pathophysiology.

TL;DR: The study demonstrates broad cellular effects of SARS-CoV-2 infection beyond classical immune cells and may serve as an entry point to develop biomarkers and targeted treatments of patients with COVID-19.