Xenia Karlsson

TL;DR: These findings represent the first documented example of selection for resistance to a synthetic gene drive and lead to important design recommendations and considerations in order to mitigate for resistance in future gene drive applications.

TL;DR: In this paper, the authors show that regulation of nuclease expression is as important as the choice of target site when developing a robust homing-based gene drive for population suppression.

TL;DR: These findings represent the first documented example of selection for resistance to a synthetic gene drive and lead to important design recommendations and considerations in order to mitigate for resistance for future gene drive applications.

TL;DR: Three new gene drives designed to restrict spatio-temporal nuclease expression by using novel regulatory sequences are described, demonstrating in laboratory-contained population experiments that these gene drives show remarkably improved invasion dynamics compared to the first generation drives.

TL;DR: It is shown that changes to regulatory sequences in the drive element, designed to contain nuclease expression to the germline, confer improved fecundity over previous versions and generate drastically lower rates of target site resistance.