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Xianbo Zhang
Researcher at Southwest University
Publications - 8
Citations - 463
Xianbo Zhang is an academic researcher from Southwest University. The author has contributed to research in topics: Gene & Transcriptome. The author has an hindex of 5, co-authored 6 publications receiving 347 citations.
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Journal ArticleDOI
Efficient and Heritable Gene Targeting in Tilapia by CRISPR/Cas9
Minghui Li,Hui-Hui Yang,Jiue Zhao,Lingling Fang,Hongjuan Shi,Mengru Li,Yun-Lv Sun,Xianbo Zhang,Dongneng Jiang,Linyan Zhou,Deshou Wang +10 more
TL;DR: The data demonstrate that targeted, heritable gene editing can be achieved in tilapia, providing a convenient and effective approach for generating loss-of-function mutants, and shows the utility of the CRISPR/Cas9 system for genetic engineering in non-model species like Tilapia and potentially in many other teleost species.
Journal ArticleDOI
Mutation of foxl2 or cyp19a1a Results in Female to Male Sex Reversal in XX Nile Tilapia.
TL;DR: Foxl2 promotes ovarian development by upregulating Cyp19a1a expression and repressing male pathway gene expression and in vitro promoter analyses consistently demonstrated that Foxl2 could suppress the transcription of star1 in a dose-dependent manner.
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gsdf is a downstream gene of dmrt1 that functions in the male sex determination pathway of the Nile tilapia
TL;DR: Results demonstrated that gsdf is a downstream gene of dmrt1, which probably inhibits estrogen production to trigger testicular differentiation, and inhibited estrogen production in a dose‐dependent manner in the presence of Sf1.
Journal ArticleDOI
Isolation of Doublesex- and Mab-3-Related Transcription Factor 6 and Its Involvement in Spermatogenesis in Tilapia
Xianbo Zhang,Hai Wang,Minghui Li,Yunying Cheng,Dongneng Jiang,Lina Sun,Wenjing Tao,Linyan Zhou,Zhijian Wang,Deshou Wang +9 more
TL;DR: The data suggest that dmrt6 also exists in bony fish, and its absence in most fish genomes was probably due to incomplete sequencing and/or secondary loss.
Journal ArticleDOI
Mutation of cyp19a1b results in sterile males due to efferent duct obstruction in Nile tilapia
TL;DR: It is demonstrated that estrogen deficiency caused by Cyp19a1b mutation resulted in male sterility due to efferent duct obstruction.