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Xiang Luo
Researcher at University of Texas Southwestern Medical Center
Publications - 59
Citations - 6506
Xiang Luo is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has an hindex of 33, co-authored 55 publications receiving 5532 citations. Previous affiliations of Xiang Luo include Huazhong University of Science and Technology.
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Journal ArticleDOI
Heart repair by reprogramming non-myocytes with cardiac transcription factors
Kunhua Song,Young-Jae Nam,Xiang Luo,Xiaoxia Qi,Wei Tan,Guo N. Huang,Asha Acharya,Christopher L. Smith,Michelle D. Tallquist,Eric G. Neilson,Joseph A. Hill,Rhonda Bassel-Duby,Eric N. Olson +12 more
TL;DR: It is shown that four transcription factors, GATA4, HAND2, MEF2C and TBX5, can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating cardiac-like myocytes in vitro and suggest a strategy for cardiac repair through reprogramming fibro Blasts resident in the heart with cardiogenic transcription factors or other molecules.
Journal ArticleDOI
Reprogramming of human fibroblasts toward a cardiac fate
Young-Jae Nam,Kunhua Song,Xiang Luo,Edward Daniel,Kaleb Lambeth,Katherine West,Joseph A. Hill,J. Michael DiMaio,Linda A. Baker,Rhonda Bassel-Duby,Eric N. Olson +10 more
TL;DR: Findings indicate that human fibroblasts can be reprogrammed to cardiac-like myocytes by forced expression of cardiac transcription factors with muscle-specific microRNAs and represent a step toward possible therapeutic application of this reprogramming approach.
Journal ArticleDOI
Gating of CFTR by the STAS domain of SLC26 transporters.
Shigeru B. H. Ko,Weizhong Zeng,Michael R. Dorwart,Xiang Luo,Kil Hwan Kim,Linda Millen,Hidemi Goto,Satoru Naruse,Abigail A. Soyombo,Philip Thomas,Shmuel Muallem +10 more
TL;DR: A reciprocal regulatory interaction between the S LC26T DRA, SLC26A6 and CFTR markedly activates CFTR by increasing its overall open probablity (NPo) sixfold and provides a new understanding of epithelial chloride and bicarbonate transport.
Journal ArticleDOI
Nitrosative stress drives heart failure with preserved ejection fraction
Gabriele G. Schiattarella,Gabriele G. Schiattarella,Francisco Altamirano,Dan Tong,Kristin M. French,Elisa Villalobos,Soo Young Kim,Xiang Luo,Nan Jiang,Herman I. May,Zhao V. Wang,Theodore M. Hill,Pradeep P.A. Mammen,Jian Huang,Dong I. Lee,Virginia S. Hahn,Kavita Sharma,David A. Kass,Sergio Lavandero,Sergio Lavandero,Thomas G. Gillette,Joseph A. Hill +21 more
TL;DR: It is reported that concomitant metabolic and hypertensive stress in mice—elicited by a combination of high-fat diet and inhibition of constitutive nitric oxide synthase using Nω-nitro-l-arginine methyl ester—recapitulates the numerous systemic and cardiovascular features of HFpEF in humans.
Journal ArticleDOI
MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²⁺ overload and cell death.
Arin B. Aurora,Ahmed I. Mahmoud,Xiang Luo,Brett A. Johnson,Eva van Rooij,Satoshi Matsuzaki,Kenneth M. Humphries,Joseph A. Hill,Rhonda Bassel-Duby,Hesham A. Sadek,Eric N. Olson +10 more
TL;DR: A pivotal role is revealed for miR-214 as a regulator of cardiomyocyte Ca²⁺ homeostasis and survival during cardiac injury, as well as repression of several downstream effectors of Ca�⁺ signaling that mediate cell death.