J. Michael DiMaio

TL;DR: It is concluded that miR-29 acts as a regulator of cardiac fibrosis and represents a potential therapeutic target for tissue fibrosis in general.

TL;DR: It is shown that the G-actin sequestering peptide thymosin β4 promotes myocardial and endothelial cell migration in the embryonic heart and retains this property in postnatal cardiomyocytes and that the pathway it regulates may be a new therapeutic target in the setting of acute myocardIAL damage.

TL;DR: Cytogenetic analysis and array comparative genomic hybridization profiling show immortalized HBECs to have duplication of parts of chromosomes 5 and 20, and microarray gene expression profiling demonstrates that the Cdk4/hTERT-immortalized bronchial cell lines clustered together and with nonimmortalization bronchia cells, distinct from lung cancer cell lines.

TL;DR: Findings indicate that human fibroblasts can be reprogrammed to cardiac-like myocytes by forced expression of cardiac transcription factors with muscle-specific microRNAs and represent a step toward possible therapeutic application of this reprogramming approach.

TL;DR: A rare missense mutation in a candidate gene, SFTPA2, within the interval encoding surfactant protein A2 (SP-A2) was identified and another rare mutation in S FTPA2 was identified in another family with IPF and lung cancer.