J
John Cijiang He
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 253
Citations - 10637
John Cijiang He is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Podocyte & Kidney disease. The author has an hindex of 54, co-authored 226 publications receiving 8243 citations. Previous affiliations of John Cijiang He include Veterans Health Administration & Shanghai Jiao Tong University.
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Genome-wide association study identifies susceptibility loci for IgA nephropathy
Ali G. Gharavi,Krzysztof Kiryluk,Murim Choi,Yifu Li,Ping Hou,Ping Hou,Jingyuan Xie,Jingyuan Xie,Simone Sanna-Cherchi,Clara J. Men,Bruce A. Julian,Robert J. Wyatt,Jan Novak,John Cijiang He,Haiyan Wang,Jicheng Lv,Li Zhu,Weiming Wang,Zhaohui Wang,Kasuhito Yasuno,Murat Gunel,Shrikant Mane,Sheila Umlauf,Irina Tikhonova,Isabel Beerman,Silvana Savoldi,Riccardo Magistroni,Gian Marco Ghiggeri,Monica Bodria,Francesca Lugani,Francesca Lugani,Pietro Ravani,Claudio Ponticelli,Landino Allegri,Giuliano Boscutti,Giovanni M. Frascà,Alessandro Amore,Licia Peruzzi,Rosanna Coppo,Claudia Izzi,Battista Fabio Viola,Prati E,Maurizio Salvadori,Renzo Mignani,Loreto Gesualdo,Francesca Bertinetto,Paola Mesiano,Antonio Amoroso,Francesco Scolari,Nan Chen,Hong Zhang,Richard P. Lifton +51 more
TL;DR: Three independent loci in the major histocompatibility complex, as well as a common deletion of CFHR1 and CFHR3 at chromosome 1q32 and a locus at chromosome 22q12 that each surpassed genome-wide significance, explain 4–7% of the disease variance and up to a tenfold variation in interindividual risk.
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AKI in hospitalized patients with COVID-19
Lili Chan,Kumardeep Chaudhary,Aparna Saha,Kinsuk Chauhan,Akhil Vaid,Shan Zhao,Ishan Paranjpe,Sulaiman Somani,Felix Richter,Riccardo Miotto,Anuradha Lala,Arash Kia,Prem Timsina,Li Li,Robert Freeman,Rong Chen,Jagat Narula,Allan C. Just,Carol R. Horowitz,Zahi A. Fayad,Carlos Cordon-Cardo,Eric E. Schadt,Matthew A. Levin,David Reich,Valentin Fuster,Barbara Murphy,John Cijiang He,Alexander W. Charney,Erwin P. Bottinger,Benjamin S. Glicksberg,Steven G. Coca,Girish N. Nadkarni +31 more
TL;DR: This retrospective, observational study involved a review of data from electronic health records of patients aged ≥18 years with laboratory-confirmed COVID-19 admitted to the Mount Sinai Health System from February 27 to May 30, 2020 to describe the frequency of AKI and dialysis requirement, AKI recovery, and adjusted odds ratios with mortality.
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Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition
Guangtao Zhang,Ruijie Liu,Ruijie Liu,Yifei Zhong,Alexander N. Plotnikov,Weijia Zhang,Lei Zeng,Elena Rusinova,Guillermo Gerona-Nevarro,Natasha Moshkina,Jennifer Joshua,Peter Y. Chuang,Michael Ohlmeyer,John Cijiang He,John Cijiang He,Ming-Ming Zhou +15 more
TL;DR: This study suggests that BET bromodomain inhibition, targeting at the proinflammatory activity of NF-κB, represents a new therapeutic approach for treating NF-σκB-mediated inflammation and kidney injury in HIVAN.
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Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells
TL;DR: AGE-R1 suppresses AGE-mediated MC inflammatory injury through negative regulation of RAGE, a previously uncharacterized pathway that may protect renal and other tissue injury due to diabetes and aging.
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Glomerular endothelial cell injury and cross talk in diabetic kidney disease.
TL;DR: Identification of novel mediators of glomerular cell cross talk, such as microRNAs, will lead to a better understanding of the pathogenesis of DKD and targeting these mediators may be a novel approach to develop more effective therapy for DKD.