Showing papers in "Kidney International in 2018"
TL;DR: The Global Burden of Disease study data and methodologies were used to describe the change in burden of CKD from 1990 to 2016 involving incidence, prevalence, death, and disability-adjusted-life-years (DALYs).
507 citations
Leiden University Medical Center1, University of Washington2, Harvard University3, Imperial College London4, Columbia University Medical Center5, Cedars-Sinai Medical Center6, University of North Carolina at Chapel Hill7, Tohoku University8, University of Oxford9, Cornell University10, Mayo Clinic11, Vanderbilt University12
TL;DR: A consensus report pertaining to the improved clarity of definitions and classification of glomerular lesions in lupus nephritis that derived from a meeting of 18 members of an international nephropathology working group in Leiden, Netherlands, in 2016 is presented.
447 citations
TL;DR: A better understanding of the mechanisms by which tubular injury drives inflammation and fibrosis is necessary for the development of therapeutics to halt the progression of chronic kidney disease.
437 citations
TL;DR: The aim is to review the rationale for renal protection with SGLT2 inhibitors, and their current place in the clinical management of patients with kidney disease.
229 citations
TL;DR: The receptor for A GEs, RAGE, is important in development of CKD, but its interaction with AGEs in vivo remains enigmatic; other ligands and ternary complexation may be influential.
209 citations
TL;DR: Regular, systematic screening for diabetic kidneys disease is needed in order to identify patients at risk of or with presymptomatic diabetic kidney disease, and annual monitoring of urinary albumin-to-creatinine ratio, estimated GFR, and blood pressure is recommended.
201 citations
TL;DR: There was considerable geographic variation in the odds of discard across the United States, which further supports the notion that factors beyond organ quality contributed to kidney discard.
170 citations
TL;DR: It is found that short-term improvement in graft survival decreased since 2000, while long- term improvement remained unchanged in Europe, illustrating an unmet need for innovation.
169 citations
TL;DR: A new classification of genetic disorders of the collagen IV α345 molecule is proposed with the goal of improving renal outcomes through regular monitoring and early treatment.
168 citations
TL;DR: A clinically applicable renal risk score for ANCA-associated GN is proposed that highlights the importance of unaffected glomeruli as a predictor of renal outcome and allows early risk prediction of ESRD.
156 citations
TL;DR: Close scrutiny of cellular and molecular pathways in repairing human kidneys is imperative for the identification of promising therapeutic targets and biomarker of human renal repair processes.
TL;DR: Results were consistent in a 12-week ambulatory blood pressure monitoring trial in 823 patients with type 2 diabetes and hypertension, and unlike HbA1c reductions, systolic blood pressure and weight reductions with empagliflozin are generally preserved in patients with chronic kidney disease.
TL;DR: This study strongly suggests that IgAN and IgA-VN have a shared feature regarding galactose-deficient IgA1-oriented pathogenesis.
TL;DR: Clinical significant arrhythmias are common in hemodialysis patients, and bradycardia and asystole rather than ventricular tachycardia may be key causes of sudden death in he Moderation of current dialysis practices could reduce the incidence of suddendeath.
University of Cape Town1, Johns Hopkins University School of Medicine2, Columbia University Medical Center3, University of California, San Francisco4, Vanderbilt University5, University of the Witwatersrand6, University of Cambridge7, National Institutes of Health8, University College London9, Baylor College of Medicine10, Icahn School of Medicine at Mount Sinai11
TL;DR: An international panel of experts in nephrology, renal pathology, and infectious diseases is convened to define the pathology of kidney disease in the setting of HIV infection, and characterize the renal risk-benefit of antiretroviral therapy for HIV treatment and prevention.
TL;DR: Increased SIRT1 activity protects against diabetes-induced podocyte injury and effectively mitigates the progression of diabetic kidney disease.
Boston Children's Hospital1, Yonsei University2, Alexandria University3, Cairo University4, Sindh Institute of Urology and Transplantation5, Centro Hospitalario Pereira Rossell6, King Abdulaziz University7, University of Minnesota8, Nationwide Children's Hospital9, Centre for Life10, Rockefeller University11, Yale University12, University of Zagreb13
TL;DR: In this article, the authors used whole exome sequencing in 51 families with at least one renal stone or with a renal ultrasound finding of nephrocalcinosis to identify the underlying molecular genetic cause of disease.
TL;DR: Low cortical oxygenation is an independent predictor of renal function decline and should stimulate studies exploring the therapeutic impact of improving renal oxygenation on renal disease progression.
Johns Hopkins University School of Medicine1, Johns Hopkins University2, Karolinska Institutet3, University Medical Center Groningen4, Geisinger Medical Center5, Tohoku University6, University of Aberdeen7, University of Toronto8, Baylor College of Medicine9, Tufts Medical Center10, University of Paris-Sud11, Utrecht University12, University of Hong Kong13, University of Freiburg14, The George Institute for Global Health15, Charité16, University of Calgary17
TL;DR: Two- and four-year models of the probability and timing of kidney failure requiring kidney replacement therapy (KRT), a non-fatal CVD event, and death according to age, sex, race, eGFR, albumin-to-creatinine ratio, systolic blood pressure, smoking status, diabetes mellitus, and history of CVD are developed.
University of Alberta1, University of Yaoundé I2, Central University of Venezuela3, University of Hassan II Casablanca4, University of Leicester5, University of Sydney6, The George Institute for Global Health7, University of Oxford8, Translational Research Institute9, Princess Alexandra Hospital10, University of California, Irvine11, Bezmialem Foundation University12, University of British Columbia13, University of Calgary14, University of Cape Town15, College of Health Sciences, Bahrain16, St. Michael's Hospital17, University of Toronto18, University of Paris19, University of Ibadan20, Tbilisi State Medical University21, Chang Gung University22
TL;DR: Significant variation is found in the global density of nephrologists and nephrology trainees and shortages in all care providers inNephrology; the gap was more prominent in low-income countries, particularly in African and South Asian ISN regions.
TL;DR: In a large, diverse American cohort of patients with C3 glomerulopathy, there is a high rate of progression to CKD and ESRD with no differences between C3GN and dense deposit disease.
Children's Hospital at Westmead1, University of Calgary2, University of Hong Kong3, University College London4, University of British Columbia5, University of Ottawa6, Pontifícia Universidade Católica do Paraná7, Ghent University Hospital8, Baylor College of Medicine9, Center for Drug Evaluation and Research10, The George Institute for Global Health11, Princess Alexandra Hospital12, Los Angeles Biomedical Research Institute13, University of Chicago14, French Institute of Health and Medical Research15, Flinders University16
TL;DR: This report outlines implementation strategies and pathways to be established through partnership with stakeholders, which may bolster acceptance and reporting of core outcomes in trials, and encourage their use by end-users such as guideline producers and policymakers to help improve patient-important outcomes.
TL;DR: Luseogliflozin prevented endothelial rarefaction and subsequent renal fibrosis after renal ischemia/reperfusion injury through a VEGF-dependent pathway induced by the dysfunction of proximal tubular glucose uptake in tubules with injury-induced GLUT2 downregulation.
TL;DR: Chronic SGLT2 inhibition is efficient in normalizing the levels of accumulated tricarboxylic acid cycle intermediates and increased oxidative stress in the kidneys of diabetic mice.
TL;DR: Dietary potassium intake plays an essential role in mediating the effect of dietary potassium intake on NCC activity and potassium homeostasis, and hypokalemia and metabolic alkalosis in kidney-specific Kir4.1 knockout mice were exacerbated by potassium restriction and only partially corrected by a high-potassium diet.
TL;DR: It is demonstrated that fibroblast growth factor 1-mediated inhibition of the renal inflammation in vivo was accompanied by attenuation of the nuclear factor κB and c-Jun N-terminal kinase signaling pathways, which holds great promise for developing new treatments for diabetic nephropathy through countering inflammatory signaling cascades in injured renal tissue.
TL;DR: Neutrophil PAD4 plays a pivotal role in renal ischemia/reperfusion-induced AKI, and transfer of neutrophils from wild-type, but not from P AD4-deficient mice, was sufficient to restore renal neutrophil extracellular trap formation and impair kidney function following renal ischemical/rePerfusion.
TL;DR: Renal IL-6 mRNA expression was increased in mice with either AKI or CKD, suggesting the kidney is the source for the increased serum IL-8 levels in the uremic state and IL- 6 contributes to the increase in FGF23 observed in CKD.
TL;DR: A chimeric fusion of rACE2 and the immunoglobulin fragment Fc segment to increase its plasma stability is generated and is suitable for future development of new renin angiotensin system-based inhibition therapies.
TL;DR: A repeat kidney biopsy may be useful in managing maintenance immunosuppression in LN, and patients in histologic remission may be candidates for withdrawal of therapy.