Showing papers by "Xiangyu Long published in 2022"
TL;DR: This article found significant relationships between prenatal maternal distress and infant amygdala-prefrontal microstructural and functional connectivity measures, and demonstrate for the first time that social support moderates these relationships.
13 citations
TL;DR: This cross-sectional study examines altered brain structure and function in children with low levels of prenatal alcohol exposure compared with well-matched unexposed children.
Abstract: This cross-sectional study examines altered brain structure and function in children with low levels of prenatal alcohol exposure compared with well-matched unexposed children.
9 citations
TL;DR: Most large health organizations recommend abstaining from alcohol during pregnancy, yet prenatal health care providers do not always convey this advice and nearly 10% of pregnant individuals report consuming alcohol.
1 citations
TL;DR: In this paper , a data-driven linked independent component analysis (ICA) was applied to explore the shared co-variation of gray and white matter measures in pre-reading language skills.
Abstract: Pre-reading language skills develop rapidly in early childhood and are related to brain structure and functional architecture in young children prior to formal education. However, the early neurobiological development that supports these skills is not well understood. Here we acquired anatomical, diffusion tensor imaging (DTI) and resting state functional MRI (rs-fMRI) from 35 children at 3.5 years of age. Children were assessed for pre-reading abilities using the NEPSY-II subtests 1 year later (4.5 years). We applied a data-driven linked independent component analysis (ICA) to explore the shared co-variation of gray and white matter measures. Two sources of structural variation at 3.5 years of age demonstrated relationships with Speeded Naming scores at 4.5 years of age. The first imaging component involved volumetric variability in reading-related cortical regions alongside microstructural features of the superior longitudinal fasciculus (SLF). The second component was dominated by cortical volumetric variations within the cerebellum and visual association area. In a subset of children with rs-fMRI data, we evaluated the inter-network functional connectivity of the left-lateralized fronto-parietal language network (FPL) and its relationship with pre-reading measures. Higher functional connectivity between the FPL and the default mode and visual networks at 3.5 years significantly predicted better Phonological Processing scores at 4.5 years. Together, these results suggest that the integration of functional networks, as well as the co-development of white and gray matter brain structures in early childhood, support the emergence of pre-reading measures in preschool children.