Xiao-Hong Yao

TL;DR: It is demonstrated that U87 cell line contained a fraction of tumor cells that could form tumor spheres and were enriched by progressively increasing the concentration of serum-free neural stem cell medium with or without low dose vincristine, a simple and effective method for isolation of CSCs to study the initiation and progression of human glioblastoma.

TL;DR: Results indicate that CXCL12 and its receptor CXCR4 promote GSC‐initiated glioma growth and angiogenesis by stimulating VEGF production.

TL;DR: Postmortem pathologic study in a ready-fordischarge COVID-19 patient who succumbed to sudden cardiovascular accident revealed SARSCoV-2-viruses remaining in pneumocytes and virus-caused pathological changes in the lungs, providing new insights into SARS-CoV- 2 pathogenesis.

TL;DR: This study demonstrates VEGFR-2 as an essential molecule to sustain the “stemness” of GSLCs, their capacity to initiate tumor vasculature, and direct initiation of tumor.

TL;DR: This study demonstrates that endothelial cells in the tumour microenvironment provide Shh to activate the HH signalling pathway in glioma cells, thereby promoting GSC properties andglioma propagation.