Chitosan-based hydrogels for controlled, localized drug delivery

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Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

Hydrogels in controlled release formulations: network design and mathematical modeling

FTIR spectroscopy characterization of poly (vinyl alcohol) hydrogel with different hydrolysis degree and chemically crosslinked with glutaraldehyde

The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems--a review.

On the importance and mechanisms of burst release in matrix-controlled drug delivery systems

Minimization of initial burst in poly(vinyl alcohol) hydrogels by surface extraction and surface-preferential crosslinking.

The initial high-rate drug release observed at the beginning of many controlled-release processes can be caused by a number of mechanisms, including surface desorption, pore diffusion, or the lack of a diffusion front barrier to regulate the diffusive process. This initial nonsteady-state period is usually referred to as "burst release." A small molecular size drug, proxyphylline, was used as a model solute to study the burst release of a drug from swellable hydrogels based on cross-linked poly(vinyl alcohol) (PVA). The influences of several factors, including drug loading concentration, initial cross-linking ratio of the polymer, initial swollen state of the hydrogel samples, pore diffusion of the drug versus swelling of the hydrogel at the beginning of the release, and osmotic pressure, were investigated to understand the burst behavior. Results show that high drug loading and low cross-linking ratio of the polymer led to more pronounced bursts. Compared to release experiments starting with relaxed samp...

Xiao Huang

Papers

On the importance and mechanisms of burst release in matrix-controlled drug delivery systems

Minimization of initial burst in poly(vinyl alcohol) hydrogels by surface extraction and surface-preferential crosslinking.

Analysis of burst release of proxyphylline from poly(vinyl alcohol) hydrogels

The Cost of Optimal Drug Delivery: Reducing and Preventing the Burst Effect in Matrix Systems