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Xiao-Yan Che
Researcher at Southern Medical University
Publications - 58
Citations - 3567
Xiao-Yan Che is an academic researcher from Southern Medical University. The author has contributed to research in topics: Dengue virus & Antigen. The author has an hindex of 28, co-authored 58 publications receiving 3063 citations. Previous affiliations of Xiao-Yan Che include University of Hong Kong.
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Journal ArticleDOI
Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways.
Yan-qing Ding,Li He,Qingling Zhang,Zhong-xi Huang,Xiao-Yan Che,Jin-lin Hou,Huijun Wang,Hong Shen,Li-wen Qiu,Zhuguo Li,Jian Geng,Jun-jie Cai,Hui-xia Han,Xin Li,Wei Kang,Desheng Weng,Ping Liang,Shibo Jiang +17 more
TL;DR: In addition to viral spread through a respiratory route, SARS‐CoV in the intestinal tract, kidney and sweat glands may be excreted via faeces, urine and sweat, thereby leading to virus transmission.
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Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS.
Li He,Yanqing Ding,Qingling Zhang,Xiao-Yan Che,Y He,Hong Shen,Huijun Wang,Zehua Li,L Zhao,Jian Geng,Yongjian Deng,Lei Yang,Jianming Li,Jun-jie Cai,Li-wen Qiu,Kun Wen,X Xu,Shibo Jiang,Shibo Jiang +18 more
TL;DR: It is suggested that cells infected by SARS‐CoV produce elevated levels of PICs which may cause immuno‐mediated damage to the lungs and other organs, resulting in ALI and, subsequently, multi‐organ dysfunction, and application of P IC antagonists may reduce the severity and mortality of SARS.
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Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation.
Jasper Fuk-Woo Chan,Kwok-Hung Chan,Garnet K. Y. Choi,Kelvin K. W. To,Herman Tse,Jian-Piao Cai,Man Lung Yeung,Vincent C.C. Cheng,Honglin Chen,Xiao-Yan Che,Susanna K. P. Lau,Patrick C. Y. Woo,Kwok-Yung Yuen +12 more
TL;DR: A cell line susceptibility study with 28 cell lines found that HCoV-EMC can infect primate, porcine, and bat cells and therefore may jump interspecies barriers and can also infect civet lung fibroblast and rabbit kidney cell lines.
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Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43.
Xiao-Yan Che,Li Wen Qiu,Zhi Yong Liao,Ya-Di Wang,Kun Wen,Yu Xian Pan,Wei Hao,Ya Bo Mei,Vincent C.C. Cheng,Kwok-Yung Yuen +9 more
TL;DR: Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs, and antigens of SARS-CoV and HCoV-OC43 were moreCross-reactive than were those of Sars-Cov and H coV-229E.
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Serotype 1-Specific Monoclonal Antibody-Based Antigen Capture Immunoassay for Detection of Circulating Nonstructural Protein NS1: Implications for Early Diagnosis and Serotyping of Dengue Virus Infections
Hua Xu,Biao Di,Yuxian Pan,Li-wen Qiu,Ya-Di Wang,Wei Hao,Li-juan He,Kwok-Yung Yuen,Xiao-Yan Che +8 more
TL;DR: The findings suggest that the serotype-specific MAb-based NS1 antigen capture ELISA may be a valuable tool for early diagnosis and serotyping of DV infections, while also providing a standardized assay for the analysis of a great number of clinical samples with convenience and cost-effectiveness.