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Xiaochuan Feng
Researcher at Tufts University
Publications - 26
Citations - 1438
Xiaochuan Feng is an academic researcher from Tufts University. The author has contributed to research in topics: Cryptosporidium parvum & Enterocytozoon bieneusi. The author has an hindex of 18, co-authored 26 publications receiving 1372 citations.
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Journal ArticleDOI
Cryptosporidium parvum in children with diarrhea in Mulago Hospital, Kampala, Uganda.
James K Tumwine,Addy Kekitiinwa,Nicolette Nabukeera,Donna E. Akiyoshi,Stephen M. Rich,Giovanni Widmer,Xiaochuan Feng,Saul Tzipori +7 more
TL;DR: Mortality rates were higher among children with severe dehydration and persistent diarrhea, and in stunted or underweight children infected with C. parvum, which remains untreatable among Ugandan children.
Journal ArticleDOI
Cryptosporidiosis and microsporidiosis in ugandan children with persistent diarrhea with and without concurrent infection with the human immunodeficiency virus
James K Tumwine,Addy Kekitiinwa,Sabrina Bakeera-Kitaka,Grace Ndeezi,Robert Downing,Xiaochuan Feng,Donna E. Akiyoshi,Saul Tzipori +7 more
TL;DR: Only HIV status was independently associated with either Cryptosporidium or E. bieneusi, with HIV being the only independent predictor of coinfection in children with PD, with and without HIV/AIDS attending Mulago National Referral Hospital.
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Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi
Donna E. Akiyoshi,Hilary G. Morrison,Shi Lei,Xiaochuan Feng,Quanshun Zhang,Nicolas Corradi,Harriet Mayanja,James K Tumwine,Patrick J. Keeling,Louis M. Weiss,Saul Tzipori +10 more
TL;DR: The findings suggest that E. bieneusi is a likely model for extreme genome reduction and host dependence, and short intergenic regions, high gene density, and shortened protein-coding sequences were observed in the E. biosporidian genome, all traits consistent with genomic compaction.
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Animal propagation and genomic survey of a genotype 1 isolate of Cryptosporidium parvum
Giovanni Widmer,Donna E. Akiyoshi,Michael A. Buckholt,Xiaochuan Feng,Stephen M. Rich,K.M Deary,C.A Bowman,Ping Xu,Yingping Wang,X Wang,Gregory A. Buck,Saul Tzipori +11 more
TL;DR: A type 1 isolate, obtained from an individual with HIV and cryptosporidiosis, was successfully adapted to propagate in gnotobiotic piglets, which should facilitate characterization of the unique features of this human pathogen.
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Infectivity of a Cryptosporidium parvum Isolate of Cervine Origin for Healthy Adults and Interferon-γ Knockout Mice
Pablo C. Okhuysen,Stephen M. Rich,Cynthia L. Chappell,Kevin A. Grimes,Giovanni Widmer,Xiaochuan Feng,Saul Tzipori +6 more
TL;DR: The infectivity of a Cryptosporidium parvum isolate of cervine origin (type 2, Moredun) propagated in calves was investigated simultaneously in healthy adult human volunteers and in interferon-gamma knockout (GKO) mice for discerning isolate-specific differences in pathogenicity.