G
Giovanni Widmer
Researcher at Tufts University
Publications - 130
Citations - 6189
Giovanni Widmer is an academic researcher from Tufts University. The author has contributed to research in topics: Cryptosporidium parvum & Cryptosporidium. The author has an hindex of 44, co-authored 123 publications receiving 5688 citations. Previous affiliations of Giovanni Widmer include University of Texas Health Science Center at Houston.
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Journal ArticleDOI
Complete genome sequence of the apicomplexan, Cryptosporidium parvum.
Mitchell S. Abrahamsen,Thomas J. Templeton,Shinichiro Enomoto,Juan E. Abrahante,Guan Zhu,Cheryl A. Lancto,Mingqi Deng,Chang Liu,Giovanni Widmer,Saul Tzipori,Gregory A. Buck,Ping Xu,Alan T. Bankier,Paul H. Dear,Bernard Anri Konfortov,Helen Spriggs,Lakshminarayan M. Iyer,Vivek Anantharaman,L. Aravind,Vivek Kapur +19 more
TL;DR: Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients in the parasite, which lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome.
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The genome of Cryptosporidium hominis
Ping Xu,Giovanni Widmer,Yingping Wang,Luiz S. Ozaki,João M. P. Alves,Myrna G. Serrano,Daniela Puiu,Patricio Manque,Donna E. Akiyoshi,Aaron J. Mackey,Aaron J. Mackey,William R. Pearson,Paul H. Dear,Alan T. Bankier,Darrell L. Peterson,Mitchell S. Abrahamsen,Vivek Kapur,Saul Tzipori,Gregory A. Buck +18 more
TL;DR: The eight-chromosome ∼9.2-million-base genome of C. hominis shows a striking concordance with the requirements imposed by the environmental niches the parasite inhabits, and phenotypic differences between these parasites must be due to subtle sequence divergence.
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Cryptosporidium hominis: experimental challenge of healthy adults.
Cynthia L. Chappell,Pablo C. Okhuysen,Rebecca C. Langer-Curry,Giovanni Widmer,Donna E. Akiyoshi,Sultan Tanriverdi,Saul Tzipori +6 more
TL;DR: The infectivity, illness, and serologic response after experimental challenge of 21 healthy adult volunteers with 10-500 C. hominis (TU502) oocysts is described and greatest responses were seen in volunteers with diarrhea and oocyst shedding.
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Cryptosporidium parvum in children with diarrhea in Mulago Hospital, Kampala, Uganda.
James K Tumwine,Addy Kekitiinwa,Nicolette Nabukeera,Donna E. Akiyoshi,Stephen M. Rich,Giovanni Widmer,Xiaochuan Feng,Saul Tzipori +7 more
TL;DR: Mortality rates were higher among children with severe dehydration and persistent diarrhea, and in stunted or underweight children infected with C. parvum, which remains untreatable among Ugandan children.
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A hundred-year retrospective on cryptosporidiosis
Saul Tzipori,Giovanni Widmer +1 more
TL;DR: Milestones include: recognition in 1980 of cryptosporidiosis as an acute enteric disease; its emergence as a chronic opportunistic infection that complicates AIDS; acknowledgement of impact on the water industry once it was shown to be waterborne; and study of Cryptosporidium genomics.