Xiaofei Chen

TL;DR: The results suggested that these potential biomarkers identified appeared to have diagnostic and/or prognostic values for HCC, which deserve to be further investigated, and suggested that RF is a classification algorithm well suited for selection of biologically relevant features in metabolomics.

TL;DR: Chemical and biochemical evidence is provided for exploring molecular mechanisms of therapeutic effects of LHQW capsule for the treatment of COVID-19 patients based on the components exposed to human and the utility of the human exposure-based approach to identify pharmaceutically active components in Chinese herb medicines is demonstrated.

TL;DR: A novel comparative normal/failing rat myocardium CMC analysis system based on online column selection and comprehensive two-dimensional chromatography/monolithic column/time-of-flight mass spectrometry was developed for parallel comparison of the chromatographic behaviors on both normal and pathological CMC columns, suitable for screening specific active components from herbal medicines by increasing the specificity of screened results.

TL;DR: The result demonstrated that the proposed comprehensive 2D HepG2/CMC/monolithic column/TOFMS system has the advantages of strong recognition and rapid analysis abilities for the total screening procedure, which will be selectable and practical in drug discovery from complex HM samples and can also be applied to other biochromatography models.

TL;DR: This study put forward for the first time a method which combined thin-layer chromatography (TLC) and surface-enhanced Raman scattering (SERS) to directly identify trace adulterant and it was found that the proposed method was simple, rapid, and accurate.