X
Xiaofei He
Researcher at Emory University
Publications - 5
Citations - 1078
Xiaofei He is an academic researcher from Emory University. The author has contributed to research in topics: Tumor necrosis factor alpha & Osteoblast. The author has an hindex of 4, co-authored 4 publications receiving 966 citations. Previous affiliations of Xiaofei He include Veterans Health Administration.
Papers
More filters
Journal ArticleDOI
Inhibition of Osteoblast Differentiation by Tumor Necrosis Factor-α
Linda C. Gilbert,Xiaofei He,Paul Farmer,Scott D. Boden,Mirek Kozlowski,Janet Rubin,Mark S. Nanes +6 more
TL;DR: It is suggested that TNF acts distal to IGF-I, BMPs, and LMP-1 in the progression toward the osteoblast phenotype as shown by continued attachment and metabolism in culture, trypan blue exclusion, and Alamar Blue cytotoxicity assay.
Journal ArticleDOI
Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2αA) is inhibited by tumor necrosis factor-α
Linda C. Gilbert,Xiaofei He,Paul K. Farmer,Janet Rubin,Hicham Drissi,Andre J. van Wijnen,Jane B. Lian,Gary S. Stein,Mark S. Nanes +8 more
TL;DR: The results indicate that TNF regulates RUNX2 expression at multiple levels including destabilization of mRNA and suppression of transcription, which may decrease osteoblast differentiation and inhibit bone formation in TNF excess states.
Journal ArticleDOI
Transcriptional Regulation of the Osterix (Osx, Sp7) Promoter by Tumor Necrosis Factor Identifies Disparate Effects of Mitogen-activated Protein Kinase and NFκB Pathways
Xianghuai Lu,Xianghuai Lu,Linda C. Gilbert,Linda C. Gilbert,Xiaofei He,Xiaofei He,Janet Rubin,Janet Rubin,Mark S. Nanes,Mark S. Nanes +9 more
TL;DR: The inhibitory effect of TNF on Osx expression may decrease OB differentiation in arthritis and osteoporosis and the roles of MAPK and NFκB were investigated as signal mediators of T NF.
Journal ArticleDOI
Inhibitory effect of NF-κB on 1,25-dihydroxyvitamin D3 and retinoid X receptor function
TL;DR: Results suggest that TNF-alpha inhibition of hormone-stimulated transcriptional activation may be mediated by activation of NF-kappaB, and the inhibitory effect of T NF-alpha on binding of receptors to DNA is unlikely to bemediated by NF- kappaB and is not necessary for inhibition of transcription.
Journal ArticleDOI
DNA hypermethylation-induced miR-182 silence targets BCL2 and HOXA9 to facilitate the self-renewal of leukemia stem cell, accelerate acute myeloid leukemia progression, and determine the sensitivity of BCL2 inhibitor venetoclax
Sisi Ye,Fang Xiong,Xiaofei He,Danyang Li,Daijiao Ye,Liuzhi Shi,Zihan Lin,Min Zhao,Shuya Feng,Bin Zhou,Huachun Weng,Lili Hong,Haige Ye,Shenmeng Gao +13 more
TL;DR: In this paper , the effects of miR-182 depletion on the overall survival and function of leukemia stem cells (LSCs) were analyzed in this mouse model in vivo.