Hicham Drissi

TL;DR: The results indicate that TNF regulates RUNX2 expression at multiple levels including destabilization of mRNA and suppression of transcription, which may decrease osteoblast differentiation and inhibit bone formation in TNF excess states.

TL;DR: Functional contributions of 5′ regulatory sequences conserved in rat, mouse and human CBFA1 genes to transcription are defined and indicate that the CB FA1 gene is autoregulated in part by negative feedback on its own promoter to stringently controlCBFA1 gene expression and function during bone formation.

TL;DR: A global analysis identified a multistage molecular and cellular cascade that supports BMP‐2‐mediated osteoblast differentiation and resulted in the discovery of a class of genes, initially described in relation to differentiation of astrocytes and oligodendrocyte that are functionally coupled to signals for cellular extensions.

TL;DR: It is established that Runx2 expression is regulated by VD3, which provides regulatory coupling between tissue-specific and steroid hormone-dependent control of genes during bone formation.

TL;DR: expression of p27 and p21 indicates that p21, which predominates in the growth period, is related to proliferation control, suggesting that p27 plays a key role in regulating osteoblast differentiation by controlling proliferation-related events in bone cells.