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Xiaohu Huang
Researcher at Peking University
Publications - 3
Citations - 465
Xiaohu Huang is an academic researcher from Peking University. The author has contributed to research in topics: MFN2 & DNAJA3. The author has an hindex of 3, co-authored 3 publications receiving 388 citations.
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Journal ArticleDOI
Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes
Ting Zhao,Xiaohu Huang,Liang Han,Xianhua Wang,Hongqiang Cheng,Yungang Zhao,Quan Chen,Ju Chen,Heping Cheng,Rui-Ping Xiao,Ming Zheng +10 more
TL;DR: A novel and essential role of MFN2 is revealed in the cardiac autophagic process by mediating the maturation of autophagy at the phase ofAutophagosome-lysosome fusion, which was markedly retarded without altering the formation of Autophagy and lysosomes in response to ischemia-reperfusion stress.
Journal ArticleDOI
A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
Wen Yue,Ziheng Chen,Hai-Yang Liu,Chen Yan,Ming Chen,Du Feng,Chaojun Yan,Hao Wu,Lei Du,Yueying Wang,Jinhua Liu,Xiaohu Huang,Laixin Xia,Lei Liu,Xiaohui Wang,Haijing Jin,Jun Wang,Zhiyin Song,Xiao-Jiang Hao,Quan Chen,Quan Chen +20 more
TL;DR: A diterpenoid derivative 15-oxospiramilactone (S3) is identified that potently induced mitochondrial fusion to restore the mitochondrial network and oxidative respiration in cells that are deficient in either Mfn1 or Mfn2.
Journal ArticleDOI
Kissing and nanotunneling mediate intermitochondrial communication in the heart
Xiaohu Huang,Lei Sun,Shuangxi Ji,Ting Zhao,Wanrui Zhang,Jiejia Xu,Jue Zhang,Yanru Wang,Xianhua Wang,Clara Franzini-Armstrong,Ming Zheng,Ming Zheng,Heping Cheng +12 more
TL;DR: It is proposed that, through kissing and nanotunneling, the otherwise static mitochondria in a cardiomyocyte form one dynamically continuous network to share content and transfer signals.