F
Fengtian He
Researcher at Third Military Medical University
Publications - 82
Citations - 3782
Fengtian He is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Downregulation and upregulation & Autophagy. The author has an hindex of 32, co-authored 82 publications receiving 3168 citations. Previous affiliations of Fengtian He include University of Michigan & University of Pittsburgh.
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Journal ArticleDOI
LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells
Haojun Xiong,Zhenhong Ni,Jintao He,S Jiang,Xiaowu Li,Wei Gong,L Zheng,Sharon C.-A. Chen,Bosheng Li,Nan Zhang,Xilin Lyu,Gang Huang,Baoliang Chen,Yujun Zhang,Fengtian He +14 more
TL;DR: The data reveals that the pathway ‘HULC/USP22/Sirt1/ protective autophagy’ attenuates the sensitivity of HCC cells to chemotherapeutic agents, suggesting that this pathway may be a novel target for developing sensitizing strategy to HCC chemotherapy.
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Cationic lipids enhance siRNA-mediated interferon response in mice
TL;DR: It is shown that although intravenous administration of siRNA alone is essentially inert, injection of si RNA complexed with cationic liposomes resulted in a potent induction of both type I and type II interferon responses.
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A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2–Beclin1 interaction at endoplasmic reticulum
Jiqin Lian,Xiaoqing Wu,Xiaoqing Wu,Fengtian He,Fengtian He,David Karnak,Wenhua Tang,Yang Meng,D Xiang,D Xiang,Meiju Ji,Theodore S. Lawrence,Liang Xu +12 more
TL;DR: The results show for the first time that (−)-gossypol can also interrupt the interactions between Beclin1 and Bcl-2/Bcl-xL at endoplasmic reticulum, thus releasing the BH3-only pro-autophagic protein BeClin1, which in turn triggers the autophagic cascade.
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Long noncoding RNA BC032469, a novel competing endogenous RNA, upregulates hTERT expression by sponging miR-1207-5p and promotes proliferation in gastric cancer.
Mu-Han Lü,Bo Tang,Shuo Zeng,Changpeng Hu,Rongkai Xie,Yu-Yun Wu,Suming Wang,Fengtian He,Yang Sm +8 more
TL;DR: BC032469 may function as a ceRNA to impair miR-1207-5p-dependent hTERT downregulation, suggesting that it may be clinically valuable as a poor prognostic biomarker of gastric cancer.
Journal ArticleDOI
Downregulation of Endothelin-1 by Farnesoid X Receptor in Vascular Endothelial Cells
Fengtian He,Jiang Li,Ying Mu,Ramalinga Kuruba,Zheng Ma,Annette Wilson,Sean Alber,Yu Jiang,Troy Stevens,Simon C. Watkins,Bruce R. Pitt,Wen Xie,Song Li +12 more
TL;DR: It is reported that farnesoid X receptor is also expressed in rat pulmonary artery endothelial cells (EC), a “nonclassical” bile acid target tissue and suggested that FXR may play a role in endothelial homeostasis and may serve as a novel molecular target for manipulating ET-1 expression in vascular EC.