Xiaoju Hu

TL;DR: It is found that the porcine lincRNAs were preferentially located near genes mediating transcriptional regulation rather than those with developmental functions, which indicates that the functions of these genes in the skeletal muscle developmental process are under investigation.

TL;DR: Analysis of ITH in lung squamous cell carcinoma at the levels of genome, transcriptome, and tumor-immune interactions and histopathological characteristics by multi-region bulk and single-cell sequencing suggests that non-genetic heterogeneity is a major determinant of heterogeneity in histopathology characteristics and impacts evolutionary dynamics in lung cancer.

TL;DR: Signs of argali introgression into domestic sheep, extensive historical mixtures among domestic populations and strong artificial selection for tail type and other traits, reflecting various breeding strategies by nomadic societies in ancient China are revealed.

TL;DR: The genomic variation in Tibetan sheep is investigated using whole-genome sequences, single nucleotide polymorphism arrays, mitochondrial DNA, and Y-chromosomal variants in 986 samples throughout their distribution range to contribute to a depth understanding of early pastoralism and the local adaptation of Tibetan sheep as well as the late-Holocene human occupation of the QTP.

TL;DR: Analyzing somatic mutation data from multiple cancer types in their epigenomic contexts, it is shown that SBS8 preferentially occurs in gene-poor, lamina-proximal, late replicating heterochromatin domains and likely arises from late replication errors during cancer progression.