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Xiaolan Zhang
Researcher at Massachusetts Institute of Technology
Publications - 7
Citations - 5007
Xiaolan Zhang is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Chromatin & Enhancer. The author has an hindex of 6, co-authored 7 publications receiving 4657 citations. Previous affiliations of Xiaolan Zhang include Broad Institute.
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Journal ArticleDOI
Mapping and analysis of chromatin state dynamics in nine human cell types
Jason Ernst,Pouya Kheradpour,Pouya Kheradpour,Tarjei S. Mikkelsen,Noam Shoresh,Lucas D. Ward,Lucas D. Ward,Charles B. Epstein,Xiaolan Zhang,Li Wang,Robbyn Issner,Michael Coyne,Manching Ku,Manching Ku,Manching Ku,Timothy Durham,Manolis Kellis,Manolis Kellis,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +20 more
TL;DR: This study presents a general framework for deciphering cis-regulatory connections and their roles in disease, and maps nine chromatin marks across nine cell types to systematically characterize regulatory elements, their cell-type specificities and their functional interactions.
Journal Article
Mapping and Analysis of Chromatin State Dynamics in Nine Human Cell Types
Jason Ernst,Pouya Kheradpour,Pouya Kheradpour,Tarjei S. Mikkelsen,Noam Shoresh,Lucas D. Ward,Lucas D. Ward,Charles B. Epstein,Xiaolan Zhang,Li Wang,Robbyn Issner,Michael Coyne,Manching Ku,Manching Ku,Manching Ku,Timothy Durham,Manolis Kellis,Manolis Kellis,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +20 more
TL;DR: This study presents a general framework for deciphering cis-regulatory connections and their roles in disease, and defines multi-cell activity profiles for chromatin state, gene expression, regulatory motif enrichment, and regulator expression.
Journal ArticleDOI
Combinatorial Patterning of Chromatin Regulators Uncovered by Genome-wide Location Analysis in Human Cells
Oren Ram,Alon Goren,Ido Amit,Ido Amit,Noam Shoresh,Nir Yosef,Nir Yosef,Jason Ernst,Jason Ernst,Manolis Kellis,Manolis Kellis,Melissa Gymrek,Robbyn Issner,Michael Coyne,Timothy Durham,Xiaolan Zhang,Julie Donaghey,Charles B. Epstein,Aviv Regev,Aviv Regev,Aviv Regev,Bradley E. Bernstein +21 more
TL;DR: This work developed ChIP-string, a meso-scale assay that combines chromatin immunoprecipitation with a signature readout of 487 representative loci that was applied to screen 145 antibodies, thereby identifying effective reagents, which were used to map the genome-wide binding of 29 CRs in two cell types.
Journal ArticleDOI
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.
Ellen Markljung,Lin Jiang,Jacob D. Jaffe,Tarjei S. Mikkelsen,Ola Wallerman,Martin Larhammar,Xiaolan Zhang,Li Wang,Veronica Saenz-Vash,Andreas Gnirke,Anders Lindroth,Romain Barrès,Jie Yan,Sara Strömberg,Sachinandan De,Fredrik Pontén,Eric S. Lander,Steven A. Carr,Juleen R. Zierath,Klas Kullander,Claes Wadelius,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Göran Andersson,Göran Hjälm,Leif Andersson,Leif Andersson +26 more
TL;DR: A previously uncharacterized protein, encoded by a domesticated DNA transposon, called ZBED6 that regulates the expression of the insulin-like growth factor 2 (IGF2) gene, and possibly numerous others, in all placental mammals including human.
Journal ArticleDOI
Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions
Jason Ernst,Alexandre Melnikov,Xiaolan Zhang,Li Wang,Peter Rogov,Tarjei S. Mikkelsen,Manolis Kellis +6 more
TL;DR: Sharpr-MPRA as mentioned in this paper combines dense tiling of overlapping MPRA constructs with a probabilistic graphical model to recognize functional regulatory nucleotides, and to distinguish activating and repressive cells using their inferred contribution to reporter gene expression.