G
Göran Hjälm
Researcher at Uppsala University
Publications - 12
Citations - 1144
Göran Hjälm is an academic researcher from Uppsala University. The author has contributed to research in topics: Calcium metabolism & Gene. The author has an hindex of 8, co-authored 12 publications receiving 1037 citations. Previous affiliations of Göran Hjälm include Rhône-Poulenc & Swedish University of Agricultural Sciences.
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Journal ArticleDOI
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice
Lisa S. Andersson,Martin Larhammar,Fatima Memic,Hanna Wootz,Doreen Schwochow,Carl-Johan Rubin,Kalicharan Patra,Thorvaldur Árnason,Lisbeth Wellbring,Göran Hjälm,Freyja Imsland,Jessica L. Petersen,Molly E. McCue,James R. Mickelson,Gus Cothran,Nadav Ahituv,Lars Roepstorff,Sofia Mikko,Anna Vallstedt,Gabriella Lindgren,Leif Andersson,Leif Andersson,Klas Kullander +22 more
TL;DR: This work shows that a premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses, and positions Dmrt3 in a pivotal role for configuring the spinal circuits controlling stride in vertebrates.
Journal ArticleDOI
Tissue distribution of human gp330/megalin, a putative Ca2+-sensing protein
Stefan Lundgren,Tobias Carling,Göran Hjälm,Claes Juhlin,Jonas Rastad,Ulla Pihlgren,Lars Rask,Göran Åkerström,Per Hellman +8 more
TL;DR: The findings substantiate human gp330/megalin expression in a variety of human tissues expected to possess calcium-sensing functions and may constitute a protein of utmost importance to adult and fetal calcium homeostasis.
Journal ArticleDOI
Expression profiling of the γ-subunit isoforms of AMP-activated protein kinase suggests a major role for γ3 in white skeletal muscle
Margit Mahlapuu,Carina Johansson,Kerstin Lindgren,Göran Hjälm,Brian R. Barnes,Anna Krook,Juleen R. Zierath,Leif Andersson,Stefan L. Marklund +8 more
TL;DR: Expression patterns of the three isoforms of the regulatory γ-subunit of AMP-activated protein kinase (AMPK) were determined in various tissues from adult humans, mice, and rats, as well as in huma...
Journal ArticleDOI
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.
Ellen Markljung,Lin Jiang,Jacob D. Jaffe,Tarjei S. Mikkelsen,Ola Wallerman,Martin Larhammar,Xiaolan Zhang,Li Wang,Veronica Saenz-Vash,Andreas Gnirke,Anders Lindroth,Romain Barrès,Jie Yan,Sara Strömberg,Sachinandan De,Fredrik Pontén,Eric S. Lander,Steven A. Carr,Juleen R. Zierath,Klas Kullander,Claes Wadelius,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Göran Andersson,Göran Hjälm,Leif Andersson,Leif Andersson +26 more
TL;DR: A previously uncharacterized protein, encoded by a domesticated DNA transposon, called ZBED6 that regulates the expression of the insulin-like growth factor 2 (IGF2) gene, and possibly numerous others, in all placental mammals including human.
Journal ArticleDOI
Cloning and Sequencing of Human gp330, a Ca2+-Binding Receptor with Potential Intracellular Signaling Properties
Göran Hjälm,Göran Hjälm,Edward M. Murray,Gregg Crumley,William Harazim,Stefan Lundgren,Isaac Onyango,Bo Ek,Mårten Larsson,Claes Juhlin,Per Hellman,Hughes Davis,Göran Åkerström,Lars Rask,Buzzy Morse +14 more
TL;DR: The intracellular tail contains not only two copies of the F(X)NPXY coated-pit mediated internalization signal characteristic of LDLR superfamily members, but also intriguing and potentially functional motifs including several Src-homology 3 recognition motifs.