Xiaolan Zhang

TL;DR: This study presents a general framework for deciphering cis-regulatory connections and their roles in disease, and maps nine chromatin marks across nine cell types to systematically characterize regulatory elements, their cell-type specificities and their functional interactions.

TL;DR: This study presents a general framework for deciphering cis-regulatory connections and their roles in disease, and defines multi-cell activity profiles for chromatin state, gene expression, regulatory motif enrichment, and regulator expression.

TL;DR: This work developed ChIP-string, a meso-scale assay that combines chromatin immunoprecipitation with a signature readout of 487 representative loci that was applied to screen 145 antibodies, thereby identifying effective reagents, which were used to map the genome-wide binding of 29 CRs in two cell types.

TL;DR: A previously uncharacterized protein, encoded by a domesticated DNA transposon, called ZBED6 that regulates the expression of the insulin-like growth factor 2 (IGF2) gene, and possibly numerous others, in all placental mammals including human.

TL;DR: Sharpr-MPRA as mentioned in this paper combines dense tiling of overlapping MPRA constructs with a probabilistic graphical model to recognize functional regulatory nucleotides, and to distinguish activating and repressive cells using their inferred contribution to reporter gene expression.