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Xiaomeng Zhang
Researcher at Peter MacCallum Cancer Centre
Publications - 24
Citations - 2573
Xiaomeng Zhang is an academic researcher from Peter MacCallum Cancer Centre. The author has contributed to research in topics: Hippo signaling pathway & Gene. The author has an hindex of 14, co-authored 19 publications receiving 2148 citations. Previous affiliations of Xiaomeng Zhang include University of Melbourne.
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Journal ArticleDOI
The Hippo pathway and human cancer
TL;DR: The evidence for the Hippo pathway as a cancer signalling network is appraised, and potential mechanisms by which Hippo pathways activity is altered in cancer and emerging therapeutic strategies are discussed.
Journal ArticleDOI
The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene
Xiaomeng Zhang,Xiaomeng Zhang,Joshy George,Joshy George,S. Deb,Joffrey L. Degoutin,Joffrey L. Degoutin,Elena A Takano,Stephen B. Fox,David D.L. Bowtell,David D.L. Bowtell,Kieran F. Harvey,Kieran F. Harvey +12 more
TL;DR: It is found that high nuclear YAP expression correlates with poor patient prognosis in a cohort of 268 invasive epithelial ovarian cancer samples and that the SWH pathway is an attractive therapeutic target.
Journal ArticleDOI
The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway.
Carole L.C. Poon,Jane I. Lin,Xiaomeng Zhang,Xiaomeng Zhang,Kieran F. Harvey,Kieran F. Harvey +5 more
TL;DR: A role for Tao-1 is described as a regulator of epithelial tissue growth that modulates activity of the core SWH pathway kinase cassette that is evolutionarily conserved and identified as a potential tumor suppressor genes.
Journal ArticleDOI
Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP
Liselotte Angus,Susana Moleirinho,Lissa R. Herron,Amit U. Sinha,Amit U. Sinha,Xiaomeng Zhang,Xiaomeng Zhang,M Niestrata,Kishan Dholakia,Michael B. Prystowsky,Kieran F. Harvey,Kieran F. Harvey,Paul A. Reynolds,F. Gunn-Moore +13 more
TL;DR: It is shown that ectopic willin expression causes an increase in phosphorylation of the core Hippo signaling pathway components MST1/2, LATS1 and YAP, an effect that can be antagonized by ezrin.
Journal ArticleDOI
Transcriptional Output of the Salvador/Warts/Hippo Pathway Is Controlled in Distinct Fashions in Drosophila melanogaster and Mammalian Cell Lines
TL;DR: Yki/YAP WW domains have distinct regulatory roles in different cell types and implies the existence of proteins that promote tissue growth in collaboration with Yki and Sd.