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Xiaosen Ouyang
Researcher at University of Alabama at Birmingham
Publications - 24
Citations - 1586
Xiaosen Ouyang is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Autophagy & Mitochondrion. The author has an hindex of 15, co-authored 24 publications receiving 1271 citations. Previous affiliations of Xiaosen Ouyang include United States Department of Veterans Affairs & Veterans Health Administration.
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Journal ArticleDOI
Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function
Nadia Jaber,Zhixun Dou,Juei-Suei Chen,Joseph M. Catanzaro,Ya-Ping Jiang,Lisa M. Ballou,Elzbieta S. Selinger,Xiaosen Ouyang,Richard Z. Lin,Jianhua Zhang,Wei-Xing Zong +10 more
TL;DR: The results indicate that Vps34 plays an essential role in regulating functional autophagy and is indispensable for normal liver and heart function.
Journal ArticleDOI
Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons
Matthew Redmann,Gloria A. Benavides,Taylor F. Berryhill,Willayat Yousuf Wani,Xiaosen Ouyang,Michelle S. Johnson,Saranya Ravi,Stephen Barnes,Victor M. Darley-Usmar,Jianhua Zhang +9 more
TL;DR: A significant impact of bafilomycin and chloroquine on cellular bioenergetics and metabolism consistent with decreased mitochondrial quality associated with inhibition of autophagy is demonstrated.
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Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress
Lonnie Schneider,Samantha Giordano,Blake R. Zelickson,Michelle S. Johnson,Gloria A. Benavides,Xiaosen Ouyang,Xiaosen Ouyang,Naomi Fineberg,Victor M. Darley-Usmar,Jianhua Zhang,Jianhua Zhang +10 more
TL;DR: In this paper, the authors used retinoic acid (RA) to induce differentiation of SH-SY5Y cells and assessed changes in cellular bioenergetics using extracellular flux analysis, finding that differentiated cells were substantially more resistant to cytotoxicity and mitochondrial dysfunction induced by reactive lipid species 4-hydroxynonenal or reactive oxygen species generator 2,3-dimethoxy-1,4-naphthoquinone.
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Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy.
Ashlee N. Higdon,Gloria A. Benavides,Balu K. Chacko,Xiaosen Ouyang,Michelle S. Johnson,Aimee Landar,Jianhua Zhang,Victor M. Darley-Usmar +7 more
TL;DR: Attenuation of lipid peroxidation may be able to preserve mitochondrial function in the endothelium and protect cells from heme-dependent toxicity through a mechanism which involves protein modification by oxidized lipids and other oxidants, decreased respiratory capacity, and a protective role for the autophagic process.
Journal ArticleDOI
Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells
Kenneth P. Hough,Jennifer Trevor,John G. Strenkowski,Yong Wang,Balu K. Chacko,Sultan Tousif,Diptiman Chanda,Chad Steele,Veena B. Antony,Terje Dokland,Xiaosen Ouyang,Jianhua Zhang,Steven R. Duncan,Victor J. Thannickal,Victor M. Darley-Usmar,Jessy S. Deshane +15 more
TL;DR: It is shown that EVs contain markers of mitochondria derived from donor cells which are capable of sustaining a membrane potential, and that these participate in intercellular communication within the airways of human subjects with asthma.