Xiaoxiao Qi

TL;DR: It is revealed that KMT2D epigenetically activates PI3K/Akt pathway and EMT by targeting LIFR and KLF4 and thus serves as a putative epigenetic-based target for treating PCa.

TL;DR: Dioscin targets Cx43 to suppress the tumor cell malignancy and activate macrophage sensitivity, thereby targeting melanoma microenvironment.

TL;DR: Findings in the current study provide evidence that p62‐Keap1‐Nrf2 axis is a pivotal signaling pathway in development of arthritis and therapeutic efficacy of drugs, and LCA activates of Keap1-NRF2 signaling to suppress arthritis by phosphorylation of p62 at Ser349.

TL;DR: This review summarizes the epigenetic mechanisms by which active compounds from Chinese herbs exert their anti-cancer effect, including curcumin and resveratrol, and a subset of these compounds affect multiple epigenetic processes, including DNMT inhibition, HDAC inactivation, MBP suppression, HAT activation, and microRNA modulation.

TL;DR: C57BL/6 mice models, with high‐dose CTX treatments for 10 days, can be an optimized animal model for chemotherapy‐induced bone marrow suppression.