Showing papers by "Xiaoyan Jiang published in 2004"
TL;DR: It is shown that in both mice and humans, Ahi-1/AHI-1 expression is highest in the most primitive hematopoietic cells with specific patterns of down-regulation in different lineages, and that perturbations in AHI-1expression may contribute to the development of specific types of human leukemia.
52 citations
TL;DR: Findings suggest a previously undescribed epigenetic mechanism of IM unresponsiveness characteristic of chronic myeloid leukemia, which is linked to a reduced IM sensitivity of the more primitive, slowly proliferating CD34 + CML cells thought to be responsible for sustaining the disease in vivo.
20 citations
TL;DR: The polymorphisms in the GNB3 gene and ACE gene, solely or combined, did not confer a significantly increased risk for the development of EH in the Kazakh isolate of northeast China.
Abstract: GNB3 gene C825T and ACE gene I/D polymorphisms in essential hypertension in a Kazakh genetic isolate
17 citations
TL;DR: It is shown that infection of normal human CD34+ cord blood cells with a retroviral vector encoding p210BCR-ABL rapidly activates a factor-independent phenotype and autocrine interleukin-3/granulocyte colony-stimulating factor/erythropoietin production in the transduced cells.
Abstract: Growth autonomy and lineage switching in BCR-ABL-transduced human cord blood cells depend on different functional domains of BCR-ABL
14 citations
TL;DR: P in vivo may offer a novel therapeutic strategy for the improved elimination of primitive quiescent CML cells that are relatively IM-insensitive.
3 citations
TL;DR: The CML clone in chronic phase patients contains a similar hierarchy of short and longterm repopulating cells as is found in normal adult bone marrow, and that the CML repopulated cells have, in addition to their ability to sustain the clone, a greater innate resistance to the toxic effects that imatinib mesylate has in vivo on the majority population of more differentiated CML cells.
2 citations