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Clayton A. Smith
Researcher at University of Colorado Denver
Publications - 155
Citations - 6587
Clayton A. Smith is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Stem cell & Transplantation. The author has an hindex of 37, co-authored 146 publications receiving 5519 citations. Previous affiliations of Clayton A. Smith include University of Colorado Boulder & BC Cancer Agency.
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Journal ArticleDOI
Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.
Daniel A. Pollyea,Brett M. Stevens,Courtney L. Jones,Amanda Winters,Shanshan Pei,Mohammad Minhajuddin,Angelo D'Alessandro,Rachel Culp-Hill,Kent Riemondy,Austin E. Gillen,Jay R. Hesselberth,Diana Abbott,Derek Schatz,Jonathan A. Gutman,Enkhtsetseg Purev,Clayton A. Smith,Craig T. Jordan +16 more
TL;DR: This report shows that treatment of older patients with AML with the B cell lymphoma 2 (BCL-2) inhibitor venetoclax in combination with azacitidine results in deep and durable remissions and is superior to conventional treatments.
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MIFlowCyt: the minimum information about a Flow Cytometry Experiment.
Jamie A. Lee,Josef Spidlen,Keith S. Boyce,Jennifer Cai,Nicholas D. Crosbie,Mark E. Dalphin,Jeff Furlong,Maura Gasparetto,M. W. Goldberg,Elizabeth M. Goralczyk,Bill Hyun,Kirstin Jansen,Tobias R. Kollmann,Megan Kong,Robert C. Leif,Shannon K. McWeeney,Thomas D. Moloshok,Wayne A. Moore,Garry P. Nolan,John P. Nolan,Janko Nikolich-Zugich,David Parrish,Barclay Purcell,Yu Qian,Biruntha Selvaraj,Clayton A. Smith,Olga Tchuvatkina,Anne M. Wertheimer,Peter Wilkinson,Christopher B. Wilson,James C. S. Wood,Robert Zigon,Richard H. Scheuermann,Ryan R. Brinkman +33 more
TL;DR: The MIFlowCyt standard includes recommendations about descriptions of the specimens and reagents included in the FCM experiment, the configuration of the instrument used to perform the assays, and the data processing approaches used to interpret the primary output data.
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Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies.
Xiaoyan Jiang,Xiaoyan Jiang,Yongjun Zhao,Clayton A. Smith,Clayton A. Smith,Maura Gasparetto,Ali G. Turhan,Allen C. Eaves,Allen C. Eaves,Connie J. Eaves +9 more
TL;DR: It is shown that the lesser effect of imatinib mesylate on the 3-week output of cells produced in vitro from lin−CD34+CD38− CML (stem) cells compared with cultures initiated with the CD38+ subset of lin− CD34+ cells is markedly enhanced when conditions of reduced growth factor stimulation are used.
Journal ArticleDOI
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
Courtney L. Jones,Brett M. Stevens,Angelo D'Alessandro,Julie A. Reisz,Rachel Culp-Hill,Travis Nemkov,Shanshan Pei,Nabilah Khan,Biniam Adane,Haobin Ye,Anna Krug,Dominik Reinhold,Clayton A. Smith,James DeGregori,Daniel A. Pollyea,Craig T. Jordan +15 more
TL;DR: It is demonstrated that amino acid uptake, steady-state levels, and catabolism are all elevated in the leukemia stem cell (LSC) population, indicating that clinically relevant eradication of LSCs can be achieved with drugs that target LSC metabolic vulnerabilities.
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Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential.
David G. Kent,David G. Kent,Michael R. Copley,Michael R. Copley,Claudia Benz,Stefan Wöhrer,Brad Dykstra,Elaine Ma,John Cheyne,Yongjun Zhao,Michelle B. Bowie,Yun Zhao,Maura Gasparetto,Allen Delaney,Clayton A. Smith,Clayton A. Smith,Marco A. Marra,Connie J. Eaves,Connie J. Eaves +18 more
TL;DR: It is shown that cells capable of repopulating irradiated congenic hosts for 4 months and producing clones of cells that can be serially transplanted are selectively and highly enriched in the CD150(+) subset of the EPCR(+)CD48(-)CD45(+) fraction of mouse fetal liver and adult bone marrow cells.