Xin-An Wang

TL;DR: IRF3 interacts with IKK β in the cytoplasm to inhibit IKKβ/NF‐κB signaling, thus alleviating hepatic inflammation, insulin resistance, and hepatic steatosis, and deletion of the region of IRf3 responsible for the IRF3/IKKβ interaction inhibits the capacity of IRF2 to preserve glucose and lipid homeostasis.

TL;DR: In this paper, the effect of baicalein on metabolic syndrome induced by a high-fat diet in mice was investigated and it was shown that AMPKα(2)-dependent mechanism involving multiple intracellular signaling pathways.

TL;DR: A role for IRF7 in diet-induced alterations in energy metabolism and insulin sensitivity is demonstrated and the results suggest that IRF 7 is involved in the etiology of metabolic abnormalities, which suggests a new strategy for treating obesity and type 2 diabetes.

TL;DR: Spondin 2 regulates hepatic lipid metabolism and alleviates hepatic steatosis, obesity, inflammation, and IR in mice via its interaction with PPARα.

TL;DR: The data suggest that loss of RGS5 exacerbates HF-induced obesity, hepatic steatosis, inflammation and insulin resistance and is accompanied by weakened Akt/GSK3β phosphorylation.