X
Xin Dong Guo
Researcher at South China University of Technology
Publications - 24
Citations - 1937
Xin Dong Guo is an academic researcher from South China University of Technology. The author has contributed to research in topics: Micelle & Drug delivery. The author has an hindex of 20, co-authored 24 publications receiving 1747 citations.
Papers
More filters
Journal ArticleDOI
Biodegradable nanostructures with selective lysis of microbial membranes
Fredrik Nederberg,Ying Zhang,Jeremy P. K. Tan,Kaijin Xu,Huaying Wang,Chuan Yang,Shujun Gao,Xin Dong Guo,Kazuki Fukushima,Lanjuan Li,James L. Hedrick,Yi Yan Yang +11 more
TL;DR: It is demonstrated that the nanoparticles disrupt microbial walls/membranes selectively and efficiently, thus inhibiting the growth of Gram-positive bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and fungi, without inducing significant haemolysis over a wide range of concentrations.
Journal ArticleDOI
Self-assembled pH-responsive MPEG-b-(PLA-co-PAE) block copolymer micelles for anticancer drug delivery
TL;DR: The results indicate the pH-sensitive MPEG-b-(PLA-co-PAE) micelle may be a potential hydrophobic drug delivery carrier for cancer targeting therapy with sustained release.
Journal ArticleDOI
pH-sensitive micelles self-assembled from multi-arm star triblock co-polymers poly(ε-caprolactone)-b-poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) for controlled anticancer drug delivery.
You Qiang Yang,Bin Zhao,Zhen Dong Li,Wenjing Lin,Can Yang Zhang,Xin Dong Guo,Jufang Wang,Lijuan Zhang +7 more
TL;DR: The results demonstrate that the pH-sensitive multilayer micelles could have great potential application in delivering hydrophobic anticancer drugs for improved cancer therapy and a lower dosage is sufficient for the same therapeutic efficacy.
Journal ArticleDOI
Dissipative Particle Dynamics Studies on Microstructure of pH-Sensitive Micelles for Sustained Drug Delivery
TL;DR: Dissipative particle dynamics simulations were performed to study the microstructures of doxorubicin loaded/blank micelles self-assembled from cholesterol conjugated His10Arg10 (HR20-Chol) at different pH conditions, demonstrating that the DPD method may provide a powerful tool in analysis and design of drug delivery systems.
Journal ArticleDOI
pH-Sensitive Micelles Self-Assembled from Amphiphilic Copolymer Brush for Delivery of Poorly Water-Soluble Drugs
TL;DR: The results indicate that the P(MMA-co-MAA)-b-PPEGMA micelle may be a potential oral drug delivery carrier for poorly water-soluble drugs.