Xin Qiao

TL;DR: The present work showed the antitumor effect of 1 on cell cycle and apoptosis, and displayed efficient oxidative cleavage of supercoiled DNA, which might indicate that the underlying mechanism involve hydroxyl radical, singlet oxygen-like species, and hydrogen peroxide as reactive oxygen species.

TL;DR: Inspiringly, complex, with salicylic acid as the auxiliary ligand, displayed a stronger anticancer activity, suggesting that a synergistic effect of the Schiff base complex and the nonsteroidal anti-inflammatory drug may be involved in the cell killing process.

TL;DR: In vitro study of the photocytotoxicity of two complexes on HeLa cells indicate that both of them have the potential to act as effective anticancer drugs, with IC(50) values of 5.25±0.83 μM and 4.40± 0.52 μM.

TL;DR: Three new zinc(II) complexes, utilizing two new and interrelated di-nucleating polypyridyl ligands, have been synthesized and characterized by using various physico-chemical techniques, which reveal that three complexes bind to CT-DNA by partial intercalation binding modes.

TL;DR: Both 1 and 2 bind to BSA with a medium affinity through a static mode which is tentatively assigned binding to Trp134 in BSA, showing the involvement of a singlet oxygen-like entity and hydrogen peroxide in the cleavage process.