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Xinbin Chen
Researcher at University of California, Davis
Publications - 205
Citations - 13680
Xinbin Chen is an academic researcher from University of California, Davis. The author has contributed to research in topics: Gene knockdown & Messenger RNA. The author has an hindex of 61, co-authored 174 publications receiving 12517 citations. Previous affiliations of Xinbin Chen include University of Alabama & University of California.
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Journal ArticleDOI
MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M.
Jianhui Zhu,Xinbin Chen +1 more
TL;DR: Results suggest that the MCG10 RNA-binding protein is a potential mediator of p53 tumor suppression.
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DNA Polymerase η, the Product of the Xeroderma Pigmentosum Variant Gene and a Target of p53, Modulates the DNA Damage Checkpoint and p53 Activation
Gang Liu,Xinbin Chen +1 more
TL;DR: PolH has a novel role in the DNA damage checkpoint and that a p53 target can modulate theDNA damage response and subsequently regulate p53 activation, which is found to be up-regulated by DNA breaks induced by ionizing radiation or chemotherapeutic agents.
Journal ArticleDOI
ΔNp73β Is Active in Transactivation and Growth Suppression
TL;DR: It is shown that the 13 unique residues at the N terminus are required for ΔNp73β to suppress cell growth, and that the N-terminal PXXP motifs constitute a novel activation domain that may have distinct functions under certain cellular circumstances.
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Functional p53 Determines Docetaxel Sensitivity in Prostate Cancer Cells
Chengfei Liu,Yezi Zhu,Wei Lou,Nagalakshmi Nadiminty,Xinbin Chen,Qinghua Zhou,Xu Bao Shi,Ralph W deVere White,Allen C. Gao +8 more
TL;DR: The objective was to establish whether docetaxel is a first line treatment for castration resistant prostate cancer or a second line treatment, and to establish a histopathological profile of the patient and to investigate the mechanisms leading to resistance.
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The Unique NH2-terminally Deleted (ΔN) Residues, the PXXP Motif, and the PPXY Motif Are Required for the Transcriptional Activity of the ΔN Variant of p63
TL;DR: It is shown that all NH2-terminally deleted p63 isoforms retain a potential in transactivation and growth suppression, and it is demonstrated that a PPXY motif shared by ΔNp63α and ΔN p63β is required for optimal transactivation of target gene promoters, suggesting that the PP XY motif is requisite for Δnp63 function.