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Xinchun Chen
Publications - 6
Citations - 837
Xinchun Chen is an academic researcher. The author has contributed to research in topics: Influenza A virus & Influenza A virus subtype H5N1. The author has an hindex of 5, co-authored 6 publications receiving 764 citations.
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The genesis and source of the H7N9 influenza viruses causing human infections in China
Tommy Tsan-Yuk Lam,Jia Wang,Jia Wang,Yongyi Shen,Yongyi Shen,Yongyi Shen,Boping Zhou,Lian Duan,CL Cheung,Chi Ma,Chi Ma,Samantha Lycett,Connie Y. H. Leung,Xinchun Chen,Lifeng Li,Lifeng Li,Wenshan Hong,Yujuan Chai,Linlin Zhou,Huyi Liang,Huyi Liang,Zhihua Ou,Zhihua Ou,Yongmei Liu,Yongmei Liu,Amber Farooqui,David J. Kelvin,Leo L.M. Poon,David K. Smith,David K. Smith,Oliver G. Pybus,Gabriel M. Leung,Gabriel M. Leung,Yuelong Shu,Robert G. Webster,Richard J. Webby,Joseph S. M. Peiris,Andrew Rambaut,Andrew Rambaut,Hongbo Zhu,Hongbo Zhu,Yi Guan,Yi Guan +42 more
TL;DR: It is shown that H7 viruses probably transferred from domestic duck to chicken populations in China on at least two independent occasions and subsequently reassorted with enzootic H9N2 viruses to generate the H7N9 outbreak lineage, and a related previously unrecognized H7n7 lineage.
Journal ArticleDOI
Dissemination, divergence and establishment of H7N9 influenza viruses in China
Tommy Tsan-Yuk Lam,Boping Zhou,Jia Wang,Yujuan Chai,Yongyi Shen,Xinchun Chen,Chi Ma,Wenshan Hong,Yin Chen,Yanjun Zhang,Lian Duan,Peiwen Chen,Junfei Jiang,Yu Zhang,Lifeng Li,Leo L.M. Poon,Richard J. Webby,David K. Smith,Gabriel M. Leung,Joseph S. M. Peiris,Edward C. Holmes,Yi Guan,Hongbo Zhu +22 more
TL;DR: It is shown that H7N9 viruses have spread from eastern to southern China and become persistent in chickens, which has led to the establishment of multiple regionally distinct lineages with different reassortant genotypes.
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Novel Reassortment of Eurasian Avian-Like and Pandemic/2009 Influenza Viruses in Swine: Infectious Potential for Humans
Hongbo Zhu,Boping Zhou,Xiaohui Fan,Tommy Tsan-Yuk Lam,Jia Wang,Jia Wang,Antony K. Chen,Xinchun Chen,Honglin Chen,Honglin Chen,Robert G. Webster,Richard J. Webby,Joseph S. M. Peiris,David K. Smith,David K. Smith,Yi Guan,Yi Guan +16 more
TL;DR: Wang et al. as discussed by the authors found that over 50% of pigs tested were seropositive for one or more H1 influenza viruses, most commonly pdm/09-like viruses.
Journal ArticleDOI
Expansion of genotypic diversity and establishment of 2009 H1N1 pandemic-origin internal genes in pigs in China
Huyi Liang,Tommy Tsan-Yuk Lam,Xiaohui Fan,Xinchun Chen,Yu Zeng,Ji Zhou,Lian Duan,Maying Tse,CM Chan,Lifeng Li,Tak-Ying Leung,Chun-Hung Yip,CL Cheung,Boping Zhou,David K. Smith,Leo L.M. Poon,Malik Peiris,Yi Guan,Hongbo Zhu,Hongbo Zhu +19 more
TL;DR: From extensive surveillance of SIVs over a 38-month period in southern China, it was found that although neither complete pdm/09 viruses nor their surface genes could persist in pigs, their internal genes did persist and became predominant, potentially replacing those of the enzootic SIV lineages.
Journal ArticleDOI
Emergence and Dissemination of a Swine H3N2 Reassortant Influenza Virus with 2009 Pandemic H1N1 Genes in Pigs in China
Xiaohui Fan,Hongbo Zhu,Boping Zhou,David K. Smith,Xinchun Chen,Tommy Tsan-Yuk Lam,Leo L.M. Poon,Malik Peiris,Yi Guan +8 more
TL;DR: This is the first evidence that swine reassortant viruses with pdm/09-like genes may have become established in the field, altering the landscape of human and swine influenza.