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Xindan Wang
Researcher at Indiana University
Publications - 45
Citations - 2683
Xindan Wang is an academic researcher from Indiana University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 22, co-authored 31 publications receiving 2217 citations. Previous affiliations of Xindan Wang include Harvard University & University of Oxford.
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Journal ArticleDOI
Organization and segregation of bacterial chromosomes
TL;DR: It is argued that the key feature of compaction is the orderly folding of DNA along adjacent segments and that this organization provides easy and efficient access for protein–DNA transactions and has a central role in driving segregation.
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Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus.
TL;DR: Evidence that ring-shaped assemblies tether the left and right chromosome arms together while traveling from the origin to the terminus at rates >50 kilobases per minute is provided, providing evidence for an active transport mechanism and support a model in which SMC complexes function by processively enlarging DNA loops.
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The two Escherichia coli chromosome arms locate to separate cell halves
TL;DR: Visualization of pairwise combinations of multiple genetic loci reveals that the two replichores occupy separate nucleoid halves, with the replication origin between; positions of loci on each replichore recapitulate the genetic map.
Journal ArticleDOI
Condensin promotes the juxtaposition of DNA flanking its loading site in Bacillus subtilis.
TL;DR: It is suggested that lengthwise condensation via loop extrusion could provide a generalizable mechanism by which condensin complexes act dynamically to individualize origins in B. subtilis and, when loaded along eukaryotic chromosomes, resolve them during mitosis.
Journal ArticleDOI
ParB spreading requires DNA bridging
Thomas G.W. Graham,Xindan Wang,Dan Song,Candice M. Etson,Antoine M. van Oijen,David Z. Rudner,Joseph J. Loparo +6 more
TL;DR: It is found that Bacillus subtilis ParB (Spo0J) is able to trap DNA loops and DNA bridging is a property of diverse ParB homologs, suggesting broad evolutionary conservation.