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Xingang Wang
Researcher at Institute of Molecular and Cell Biology
Publications - 24
Citations - 1133
Xingang Wang is an academic researcher from Institute of Molecular and Cell Biology. The author has contributed to research in topics: Zebrafish & Medicine. The author has an hindex of 14, co-authored 17 publications receiving 980 citations. Previous affiliations of Xingang Wang include Agency for Science, Technology and Research & National University of Singapore.
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Journal ArticleDOI
Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model
Philip M. Elks,Fredericus J.M. van Eeden,Giles Dixon,Xingang Wang,Constantino Carlos Reyes-Aldasoro,Philip W. Ingham,Moira K. B. Whyte,Sarah R. Walmsley,Stephen A. Renshaw +8 more
TL;DR: It is demonstrated that Hif-1α regulates neutrophil function in complex ways during inflammation resolution in vivo, and site-directed mutagenesis of Hif in vivo reveals that hydroxylation of HIF-1 α by prolyl hydoxylases critically regulates the Hif pathway in zebrafish neutrophils.
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Anti-Müllerian hormone and 11 β-hydroxylase show reciprocal expression to that of aromatase in the transforming gonad of zebrafish males
Xingang Wang,László Orbán +1 more
TL;DR: Gene expression analysis of anti‐Müllerian hormone, ovarian aromatase and 11β‐hydroxylase in zebrafish males indicates that amh is a candidate gene down‐regulating cyp19a1a, leading to “juvenile ovary‐to‐testis” transformation.
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The timing and extent of 'juvenile ovary' phase are highly variable during zebrafish testis differentiation
TL;DR: The differentiating zebrafish testis shows morphological features similar to those of the transforming gonad of protogynous hermaphrodites, and therefore, it could be a good model for the study of the process of female-to-male sex change in adult teleosts.
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Transcriptomic Analyses Reveal Novel Genes with Sexually Dimorphic Expression in the Zebrafish Gonad and Brain
Rajini Sreenivasan,Minnie Cai,Richárd Bártfai,Xingang Wang,Xingang Wang,Alan Christoffels,Alan Christoffels,László Orbán,László Orbán +8 more
TL;DR: A gonad-derived cDNA microarray from zebrafish was generated and demonstrated its usefulness in identifying genes with sexually dimorphic co-expression in both the gonads and the brains, and provided the first evidence of large-scale differential gene expression between female and male brains of a teleost.
Journal ArticleDOI
Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury, and models of disease
Claudia Seger,Claudia Seger,Murray Hargrave,Xingang Wang,Ruth Jinfen Chai,Stone Elworthy,Philip W. Ingham,Philip W. Ingham,Philip W. Ingham +8 more
TL;DR: This work identifies Pax7+ve myogenic cells in the zebrafish and characterize their behavior in postembryonic stages and monitored cell proliferation and myogenic regulatory factor expression in myogenic precursors cells and muscle fibers after injury using proliferation markers and the transgenic lines.