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Xingjun Fan
Researcher at Case Western Reserve University
Publications - 25
Citations - 746
Xingjun Fan is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Glycation & Ascorbic acid. The author has an hindex of 15, co-authored 22 publications receiving 671 citations. Previous affiliations of Xingjun Fan include Georgia Regents University.
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Journal ArticleDOI
Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model.
Xingjun Fan,Lixing W. Reneker,Mark E. Obrenovich,Christopher Strauch,Rongzhu Cheng,Simon M. Jarvis,Beryl J. Ortwerth,Vincent M. Monnier +7 more
TL;DR: Data strongly implicate vitamin C in lens crystallin aging and may serve as a model for protein aging in other tissues particularly rich in vitamin C, such as the hippocampal neurons and the adrenal gland.
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Methylglyoxal-bovine serum albumin stimulates tumor necrosis factor alpha secretion in RAW 264.7 cells through activation of mitogen-activating protein kinase, nuclear factor κB and intracellular reactive oxygen species formation
TL;DR: The hypothesis that MGO-modified proteins may cause TNFalpha secretion in macrophage-like RAW 264.7 cells is tested and the presence of chronically elevated levels of Mgo-modified bovine serum albumin may contribute to elevated Levels of TNF alpha in diabetes.
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UVA Light-excited Kynurenines Oxidize Ascorbate and Modify Lens Proteins through the Formation of Advanced Glycation End Products IMPLICATIONS FOR HUMAN LENS AGING AND CATARACT FORMATION
Mikhail Linetsky,Cibin T. Raghavan,Kaid Johar,Xingjun Fan,Vincent M. Monnier,Abhay R. Vasavada,Ram H. Nagaraj +6 more
TL;DR: The data suggest that kynurenine-mediated ASC oxidation followed by AGE formation may be an important mechanism for lens aging and the development of senile cataracts in humans.
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Glucosepane: a poorly understood advanced glycation end product of growing importance for diabetes and its complications
TL;DR: While several AGEs are associated and predict complication progression, the glucose/fructose-lysine/glucosepane AGE axis is one of the most robust markers for microvascular disease, especially retinopathy, in spite of adjustment for past or future average glycemia.
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Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis
Xingjun Fan,David R. Sell,Jianye Zhang,Ina Nemet,Mathilde Theves,Jie Lu,Christopher Strauch,Marc K. Halushka,Vincent M. Monnier +8 more
TL;DR: Overall, the data suggest that oxoaldehyde stress involving methylglyoxal from either glucose or ascorbate is predominant in the aging noncataractous lens, whereas aging skin collagen undergoes combined attack by nonoxidative glucose-mediated modifications, as well as those from metal-catalyzed oxidation and H(2)O(2).