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Xingyu Du
Researcher at Tsinghua University
Publications - 5
Citations - 332
Xingyu Du is an academic researcher from Tsinghua University. The author has contributed to research in topics: Excitatory postsynaptic potential & Chemistry. The author has an hindex of 1, co-authored 2 publications receiving 288 citations. Previous affiliations of Xingyu Du include Peking University.
Papers
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Structure of Mpro from COVID-19 virus and discovery of its inhibitors
Zhenming Jin,Zhenming Jin,Xingyu Du,Ya-Xi Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xingzhou Li,L. Z. Zhang,Chao Peng,Yinkai Duan,Jing Yu,Linfang Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xuejie Yang,Tian You,Liu X,Fang Bai,He-Qun Liu,Luke W. Guddat,Wenbo Xu,Wenbo Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Haiying Jiang,Haiying Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +33 more
TL;DR: The results demonstrate the efficacy of this screening strategy, which can lead to the rapid discovery of drug leads with clinical potential in response to new infectious diseases where no specific drugs or vaccines are available.
Journal ArticleDOI
Tuning the Size of Large Dense‐Core Vesicles and Quantal Neurotransmitter Release via Secretogranin II Liquid–Liquid Phase Separation
Zhaohan Lin,Yinglin Li,Yuqi Hang,Changhe Wang,Bing Liu,Jie Li,Lili Yin,Xiaohan Jiang,Xingyu Du,Zhongjun Qiao,Feipeng Zhu,Zhe Zhang,Quanfeng Zhang,Zhuan Zhou +13 more
TL;DR: It is reported that secretogranin II (SgII), a vesicle matrix protein, contributes to LDCV size regulation through its liquid–liquid phase separation in neuroendocrine cells and is shown to be a unique intravesicular matrix protein undergoing liquid– liquid phase separation.
Journal ArticleDOI
Ca2+‐independent transmission at the central synapse formed between dorsal root ganglion and dorsal horn neurons
Yuan Wang,Rong Huang,Zuying Chai,Changhe Wang,Xingyu Du,Yuqi Hang,Yongxin Xu,Jie Li,Xiaohan Jiang,Xi Wu,Zhongjun Qiao,Yinglin Li,Bing Liu,Xian-You Zhang,Peng Cao,Feipeng Zhu,Zhuan Zhou +16 more
TL;DR: In the central transmission from presynaptic (dorsal root ganglion) to postsynaptic (spinal dorsal horn) neurons in vitro, excitatory post synaptic currents (EPSCs) are mediated by glutamate transmission through both CiVDS and CDS, and an essential component of activity-induced EPSCs is mediated by CiV DS in a central synapse.
Journal ArticleDOI
Ca2+-independent but voltage dependent transmission (CiVDS) at a central synapse formed between dorsal root ganglion and dorsal horn neurons.
Yuan Wang,Rong Huang,Zuying Chai,Changhe Wang,Xingyu Du,Yuqi Hang,Jie Li,Xiaohan Jiang,Xi Wu,Zhongjun Qiao,Yinglin Li,Bing Liu,Pengfei Cao,Feipeng Zhu,Zhuan Zhou +14 more
TL;DR: In this paper , it was shown that Ca-independent but voltage-dependent secretion (CiVDS) is sufficient to trigger synaptic transmission in the somata of primary sensory and sympathetic neurons in mammals.
Posted ContentDOI
Calcium-independent but voltage-dependent secretion (CiVDS) mediates synaptic transmission in a mammalian central synapse
Yuan Wang,Rong Huang,Zuying Chai,Changhe Wang,Xingyu Du,Xingyu Du,Yuqi Hang,Yuqi Hang,Yongxin Xu,Jie Li,Xiaohan Jiang,Xi Wu,Xi Wu,Zhongjun Qiao,Yang Li,Bing Liu,Xianying Zhang,Peng Cao,Feipeng Zhu,Zhuan Zhou +19 more
TL;DR: In this paper, it was shown that an essential component of activity induced EPSCs is mediated by CiVDS in a central synapse, and that the fusion machinery of Ci-VDS includes Cav2.2 (voltage sensor) and SNARE (fusion pore).