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Chao Peng
Researcher at Chinese Academy of Sciences
Publications - 9
Citations - 3612
Chao Peng is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Drug repositioning & Virtual screening. The author has an hindex of 6, co-authored 9 publications receiving 2130 citations. Previous affiliations of Chao Peng include ShanghaiTech University.
Papers
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Journal ArticleDOI
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Zhenming Jin,Zhenming Jin,Xiaoyu Du,Yechun Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xiaofeng Li,Leike Zhang,Chao Peng,Yinkai Duan,Jing Yu,Lin Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xing-Lou Yang,Tian You,Liu X,Xiuna Yang,Fang Bai,Hong Liu,Xiang Liu,Luke W. Guddat,Wenqing Xu,Wenqing Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Hualiang Jiang,Hualiang Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +35 more
TL;DR: A programme of structure-assisted drug design and high-throughput screening identifies six compounds that inhibit the main protease of SARS-CoV-2, demonstrating the ability of this strategy to isolate drug leads with clinical potential.
ComponentDOI
Structure of Mpro from COVID-19 virus and discovery of its inhibitors
Zhenming Jin,Zhenming Jin,Xingyu Du,Ya-Xi Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xingzhou Li,L. Z. Zhang,Chao Peng,Yinkai Duan,Jing Yu,Linfang Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xuejie Yang,Tian You,Liu X,Fang Bai,He-Qun Liu,Luke W. Guddat,Wenbo Xu,Wenbo Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Haiying Jiang,Haiying Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +33 more
TL;DR: The results demonstrate the efficacy of this screening strategy, which can lead to the rapid discovery of drug leads with clinical potential in response to new infectious diseases where no specific drugs or vaccines are available.
Posted ContentDOI
SARS-CoV-2 neutralizing serum antibodies in cats: a serological investigation
Qinglu Zhang,Huixuan Zhang,Kun Huang,Ying Yang,Xianfeng Hui,Junxiang Gao,Xinglin He,Chengfei Li,Wenxiao Gong,Yashu Zhang,Chao Peng,Xi-Yan Gao,Chen H,Zhong Zou,Zhengli Shi,Minliang Jin +15 more
TL;DR: It is demonstrated that SARS-CoV-2 has infected cat population in Wuhan during the outbreak, and specific serum antibodies detected by indirect enzyme linked immunosorbent assay (ELISA) proved positive for the receptor binding domain (RBD) of the virus.
Journal ArticleDOI
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332.
Posted ContentDOI
Structure-based drug design, virtual screening and high-throughput screening rapidly identify antiviral leads targeting COVID-19
Zhenming Jin,Zhenming Jin,Xiaoyu Du,Yechun Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xiaofeng Li,Leike Zhang,Chao Peng,Yinkai Duan,Jing Yu,Lin Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xing-Lou Yang,Tian You,Liu X,Xiuna Yang,Fang Bai,Hong Liu,Xiang Liu,Luke W. Guddat,Wenqing Xu,Wenqing Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Hualiang Jiang,Hualiang Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +35 more
TL;DR: The results demonstrate the efficacy of this screening strategy, and establishes a new paradigm for the rapid discovery of drug leads with clinical potential in response to new infectious diseases where no specific drugs or vaccines are available.